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Literature DB >> 313906

Effect of protein deficiency on suppressor cells.

Abstract

The effects of moderate protein deficiency on the in vitro response of spleen cells to phytohemagglutinin in A/Jax mice were studied. The response of spleen cells from protein-deficient mice to phytohemagglutinin was found to be enhanced as compared with that of cells from control animals. Since inadequate development or function of suppressor cells in the protein-deficient mice offered a possible explanation for the enhanced lymphoproliferative activity, cocultures of spleen cells from protein-deficient and control animals were tested for their responses to phytohemagglutinin. Suppression of [3H]thymidine incorporation was detected in coculture of 25% mitomycin-treated spleen cells from control animals and 75% spleen cells from protein-deficient mice. The suppressor (regulator) elements in control spleens were found to reside in the adherent cell population.

Entities: Chemical Disease Species

Mesh：

Substances：
Phytohemagglutinins

Year: 1979 PMID： 313906 PMCID： PMC414372 DOI： 10.1128/iai.24.3.770-773.1979

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

14 in total

4. Regulation of lymphocyte responses in vitro. 3. Inhibition by adherent cells of the T-lymphocyte response to phytohemagglutinin.

Authors: H Folch; M Yoshinaga; B H Waksman
Journal: J Immunol Date: 1973-03 Impact factor: 5.422

9. Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice.

Authors: H Kirchner; A V Muchmore; T M Chused; H T Holden; R B Herberman
Journal: J Immunol Date: 1975-01 Impact factor: 5.422

10. Influence of dietary protein restriction on immune competence. I. Effect on the capacity of cells from various lymphoid organs to induce graft-vs.-host reactions.

Authors: R G Bell; L A Hazell
Journal: J Exp Med Date: 1975-01-01 Impact factor: 14.307

2 in total

1. Alteration of cell-mediated immunity to Listeria monocytogenes in protein-malnourished mice treated with thymosin fraction V.

Authors: T M Petro; G Chien; R R Watson
Journal: Infect Immun Date: 1982-08 Impact factor: 3.441

2. Effect of dietary essential amino acid limitations upon the susceptibility to Salmonella typhimurium and the effect upon humoral and cellular immune responses in mice.

Authors: T M Petro; J K Bhattacharjee
Journal: Infect Immun Date: 1981-04 Impact factor: 3.441

2 in total

Effect of protein deficiency on suppressor cells.

1. Differential characterization of the "reticulum cell" in lymphoreticular neoplasms.

2. Influence of protein restriction on immune functions in NZB mice.

3. Immune responses in malnourished children.

4. Regulation of lymphocyte responses in vitro. 3. Inhibition by adherent cells of the T-lymphocyte response to phytohemagglutinin.

5. Esterases in human leukocytes.

6. How protein deficiency enhances cellular immunity.

7. Effects of protein insufficiency on immune responsiveness.

8. Absence of enhancing antibody in cell mediated immunity to tumour heterografts in protein deficient rats.

9. Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice.

10. Influence of dietary protein restriction on immune competence. I. Effect on the capacity of cells from various lymphoid organs to induce graft-vs.-host reactions.

1. Alteration of cell-mediated immunity to Listeria monocytogenes in protein-malnourished mice treated with thymosin fraction V.

2. Effect of dietary essential amino acid limitations upon the susceptibility to Salmonella typhimurium and the effect upon humoral and cellular immune responses in mice.