Literature DB >> 31390331

What will Happen in the World of COPD 2030?

Richard E K Russell1,2, Mona Bafadhel1.   

Abstract

2030 may seem to be a long way into the future, but it's not. We live in a world of relentless rapid change in modern medicine and our approach to our patients with chronic diseases such as chronic obstructive pulmonary disease (COPD) will need to evolve at speed. This review looks at what may occur in society and medicine that will influence the way we manage COPD. The article is the opinion of the authors and is based upon current research at the cutting edge of management with a degree of gazing into a dimly lit crystal ball. COPD is a current epidemic, and this is likely to continue. Legislative efforts to reduce smoking will continue and hopefully accelerate, but this will not be globally accepted or successful. Technological advances will occur that will lead to miniaturization and the rise of near patient testing. This itself will enable a personalised approach to management with the ability to measure rapidly biomarkers which will direct therapy. The blood eosinophil is the most promising of these and is available now. New developments in the identification of disease clusters and phenotypes will also enhance a more personalised approach. Through both these epidemiological studies and also new developments in the understanding of basic mechanisms it is hoped that in the future patients will be given treatments that may fundamentally change the prognosis of COPD. Small molecule and antibody directed therapies may, if given early enough, stop and even possibly reverse the effects of COPD on cells and organs. Of course, the most important step which is achievable now is to ban all tobacco-based products from the world.

Entities:  

Year:  2019        PMID: 31390331      PMCID: PMC6777654          DOI: 10.5152/TurkThoracJ.2019.190307

Source DB:  PubMed          Journal:  Turk Thorac J        ISSN: 2148-7197


  33 in total

1.  Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).

Authors:  David Couper; Lisa M LaVange; MeiLan Han; R Graham Barr; Eugene Bleecker; Eric A Hoffman; Richard Kanner; Eric Kleerup; Fernando J Martinez; Prescott G Woodruff; Stephen Rennard
Journal:  Thorax       Date:  2013-09-12       Impact factor: 9.139

2.  Blood eosinophil count: a biomarker of an important treatable trait in patients with airway disease.

Authors:  Ian D Pavord; Alvar Agusti
Journal:  Eur Respir J       Date:  2016-05       Impact factor: 16.671

3.  Are COPD and cardiovascular disease fundamentally intertwined?

Authors:  Mona Bafadhel; Richard E K Russell
Journal:  Eur Respir J       Date:  2016-05       Impact factor: 16.671

4.  Mild chronic obstructive pulmonary disease: why spirometry is not sufficient!

Authors:  Amany F Elbehairy; Grace Parraga; Katherine A Webb; J Alberto Neder; Denis E O'Donnell
Journal:  Expert Rev Respir Med       Date:  2017-06-05       Impact factor: 3.772

Review 5.  Development of new drugs for COPD.

Authors:  Peter J Barnes
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

6.  Eosinophils in COPD: are we nearly there yet?

Authors:  Mona Bafadhel
Journal:  Lancet Respir Med       Date:  2017-11-13       Impact factor: 30.700

7.  Gene expression profile of human lung in a relatively early stage of COPD with emphysema.

Authors:  Ina Jeong; Jae-Hyun Lim; Dong Kyu Oh; Woo Jin Kim; Yeon-Mok Oh
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2018-08-28

8.  Telehealth for patients with chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis protocol.

Authors:  Violeta Gaveikaite; Claudia Fischer; Helen Schonenberg; Steffen Pauws; Spyros Kitsiou; Ioanna Chouvarda; Nicos Maglaveras; Josep Roca
Journal:  BMJ Open       Date:  2018-09-19       Impact factor: 2.692

9.  A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

Authors:  Sreekumar G Pillai; Dongliang Ge; Guohua Zhu; Xiangyang Kong; Kevin V Shianna; Anna C Need; Sheng Feng; Craig P Hersh; Per Bakke; Amund Gulsvik; Andreas Ruppert; Karin C Lødrup Carlsen; Allen Roses; Wayne Anderson; Stephen I Rennard; David A Lomas; Edwin K Silverman; David B Goldstein
Journal:  PLoS Genet       Date:  2009-03-20       Impact factor: 5.917

10.  Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

Authors:  Michael A Ghebre; Mona Bafadhel; Dhananjay Desai; Suzanne E Cohen; Paul Newbold; Laura Rapley; Jo Woods; Paul Rugman; Ian D Pavord; Chris Newby; Paul R Burton; Richard D May; Chris E Brightling
Journal:  J Allergy Clin Immunol       Date:  2014-08-13       Impact factor: 10.793

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