Literature DB >> 24029743

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).

David Couper1, Lisa M LaVange, MeiLan Han, R Graham Barr, Eugene Bleecker, Eric A Hoffman, Richard Kanner, Eric Kleerup, Fernando J Martinez, Prescott G Woodruff, Stephen Rennard.   

Abstract

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.

Entities:  

Keywords:  COPD Exacerbations; COPD epidemiology; Emphysema; Imaging/CT MRI etc

Mesh：

Substances：

Year:  2013        PMID： 24029743      PMCID： PMC3954445          DOI： 10.1136/thoraxjnl-2013-203897

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  4 in total

1.  Chronic obstructive pulmonary disease biomarker(s) for disease activity needed--urgently.

Authors:  Jørgen Vestbo; Stephen Rennard
Journal:  Am J Respir Crit Care Med       Date:  2010-10-01       Impact factor: 21.405

2.  Deaths: preliminary data for 2008.

Authors:  Arialdi M Miniño; Jiaquan Xu; Kenneth D Kochanek
Journal:  Natl Vital Stat Rep       Date:  2010-12

3.  Genetic epidemiology of COPD (COPDGene) study design.

Authors:  Elizabeth A Regan; John E Hokanson; James R Murphy; Barry Make; David A Lynch; Terri H Beaty; Douglas Curran-Everett; Edwin K Silverman; James D Crapo
Journal:  COPD       Date:  2010-02       Impact factor: 2.409

4.  Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE).

Authors:  J Vestbo; W Anderson; H O Coxson; C Crim; F Dawber; L Edwards; G Hagan; K Knobil; D A Lomas; W MacNee; E K Silverman; R Tal-Singer
Journal:  Eur Respir J       Date:  2008-01-23       Impact factor: 16.671
  4 in total
  158 in total

1.  Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study.

Authors:  A T Chin; J Rylance; S Makumbirofa; S Meffert; T Vu; J Clayton; P Mason; P Woodruff; J Metcalfe
Journal:  Int J Tuberc Lung Dis       Date:  2019-02-01       Impact factor: 2.373

2.  NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort.

Authors:  Wassim W Labaki; Meng Xia; Susan Murray; Jeffrey L Curtis; R Graham Barr; Surya P Bhatt; Eugene R Bleecker; Nadia N Hansel; Christopher B Cooper; Mark T Dransfield; J Michael Wells; Eric A Hoffman; Richard E Kanner; Robert Paine; Victor E Ortega; Stephen P Peters; Jerry A Krishnan; Russell P Bowler; David J Couper; Prescott G Woodruff; Fernando J Martinez; Carlos H Martinez; MeiLan K Han
Journal:  Respir Med       Date:  2018-06-05       Impact factor: 3.415

3.  Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).

Authors:  Madeline A Morris; Sean R Jacobson; Gregory L Kinney; Donald P Tashkin; Prescott G Woodruff; Eric A Hoffman; Richard E Kanner; Christopher B Cooper; M Brad Drummond; R Graham Barr; Elizabeth C Oelsner; Barry J Make; MeiLan K Han; Nadia N Hansel; Wanda K O'Neal; Russell P Bowler
Journal:  Chronic Obstr Pulm Dis       Date:  2018-01-24

Review 4.  Evolving Concepts in Chronic Obstructive Pulmonary Disease Blood-Based Biomarkers.

Authors:  Mario Cazzola; Ermanno Puxeddu; Josuel Ora; Paola Rogliani
Journal:  Mol Diagn Ther       Date:  2019-10       Impact factor: 4.074

5.  Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol.

Authors:  Charlie Strange; Robert M Senior; Frank Sciurba; Scott O'Neal; Alison Morris; Stephen R Wisniewski; Russell Bowler; Harry S Hochheiser; Michael J Becich; Yingze Zhang; Joseph K Leader; Barbara A Methé; Naftali Kaminski; Robert A Sandhaus
Journal:  Ann Am Thorac Soc       Date:  2015-10

6.  Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function.

Authors:  Prescott G Woodruff; R Graham Barr; Eugene Bleecker; Stephanie A Christenson; David Couper; Jeffrey L Curtis; Natalia A Gouskova; Nadia N Hansel; Eric A Hoffman; Richard E Kanner; Eric Kleerup; Stephen C Lazarus; Fernando J Martinez; Robert Paine; Stephen Rennard; Donald P Tashkin; MeiLan K Han
Journal:  N Engl J Med       Date:  2016-05-12       Impact factor: 91.245

7.  Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample. The MESA lung study.

Authors:  Eric A Hoffman; Firas S Ahmed; Heather Baumhauer; Mathew Budoff; J Jeffrey Carr; Richard Kronmal; S Reddy; R Graham Barr
Journal:  Ann Am Thorac Soc       Date:  2014-07

8.  Occupational exposures and chronic obstructive pulmonary disease. Causality established, time to focus on effect and phenotypes.

Authors:  Carlos H Martinez; George L Delclos
Journal:  Am J Respir Crit Care Med       Date:  2015-03-01       Impact factor: 21.405

9.  Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.

Authors:  Jason D Keene; Sean Jacobson; Katerina Kechris; Gregory L Kinney; Marilyn G Foreman; Claire M Doerschuk; Barry J Make; Jeffrey L Curtis; Stephen I Rennard; R Graham Barr; Eugene R Bleecker; Richard E Kanner; Eric C Kleerup; Nadia N Hansel; Prescott G Woodruff; MeiLan K Han; Robert Paine; Fernando J Martinez; Russell P Bowler; Wanda K O'Neal
Journal:  Am J Respir Crit Care Med       Date:  2017-02-15       Impact factor: 21.405

10.  Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.

Authors:  Carlos H Martinez; Alejandro A Diaz; Catherine Meldrum; Jeffrey L Curtis; Christopher B Cooper; Cheryl Pirozzi; Richard E Kanner; Robert Paine; Prescott G Woodruff; Eugene R Bleecker; Nadia N Hansel; R Graham Barr; Nathaniel Marchetti; Gerard J Criner; Ella A Kazerooni; Eric A Hoffman; Brian D Ross; Craig J Galban; Christine T Cigolle; Fernando J Martinez; MeiLan K Han
Journal:  Am J Respir Crit Care Med       Date:  2017-02-15       Impact factor: 21.405
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