Literature DB >> 3138970

Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses.

H S Banga1, R K Walker, L K Winberry, S E Rittenhouse.   

Abstract

Thrombin stimulates phospholipase C and inhibits adenylate cyclase in human platelets. We have studied the effect of purified S1 monomer, the ADP-ribosylating subunit of pertussis toxin, on these receptor-coupled G-protein-dependent activities. ADP-ribosylation of a 41 kDa protein is associated with a marked decrease in the ability of thrombin to inhibit cyclic AMP formation, but has little effect on phospholipase C. Therefore adenylate cyclase and phospholipase C appear to be modulated by different G-proteins.

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Year:  1988        PMID： 3138970      PMCID： PMC1149138          DOI： 10.1042/bj2520297

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  Inositol 1,4,5-trisphosphate and inositol 1,2-cyclic 4,5-trisphosphate are minor components of total mass of inositol trisphosphate in thrombin-stimulated platelets. Rapid formation of inositol 1,3,4-trisphosphate.

Authors:  A P Tarver; W G King; S E Rittenhouse
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

2.  Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.

Authors:  D Cassel; T Pfeuffer
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

3.  Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.

Authors:  L F Brass; C C Shaller; E J Belmonte
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

4.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

5.  Production of diglyceride from phosphatidylinositol in activated human platelets.

Authors:  S Rittenhouse-Simmons
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

6.  Stimulus-response coupling in a cell-free platelet membrane system. GTP-dependent release of Ca2+ by thrombin, and inhibition by pertussis toxin and a monoclonal antibody that blocks calcium release by IP3.

Authors:  F O'Rourke; G B Zavoico; L H Smith; M B Feinstein
Journal:  FEBS Lett       Date:  1987-04-06       Impact factor: 4.124

7.  The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

Authors:  T Katada; G M Bokoch; J K Northup; M Ui; A G Gilman
Journal:  J Biol Chem       Date:  1984-03-25       Impact factor: 5.157

8.  Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit.

Authors:  H S Banga; R K Walker; L K Winberry; S E Rittenhouse
Journal:  J Biol Chem       Date:  1987-11-05       Impact factor: 5.157

9.  Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.

Authors:  S E Rittenhouse
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

10.  Dynamic fatty acylation of p21N-ras.

Authors:  A I Magee; L Gutierrez; I A McKay; C J Marshall; A Hall
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598
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  7 in total

1.  Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.

Authors:  G R Post; L R Collins; E D Kennedy; S A Moskowitz; A M Aragay; D Goldstein; J H Brown
Journal:  Mol Biol Cell       Date:  1996-11       Impact factor: 4.138

2.  Subcellular distribution of alpha 2-adrenergic receptors, pertussis-toxin substrate and adenylate cyclase in human platelets.

Authors:  M A Zamorski; J C Ferraro; R R Neubig
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

3.  Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets.

Authors:  W G King; G L Kucera; A Sorisky; J Zhang; S E Rittenhouse
Journal:  Biochem J       Date:  1991-09-01       Impact factor: 3.857

4.  Stimulatory effect of staphylococcal leukocidin on phosphoinositide metabolism in rabbit polymorphonuclear leukocytes.

Authors:  X Wang; M Noda; I Kato
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

5.  G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

Authors:  S Offermanns; K L Laugwitz; K Spicher; G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

6.  Thromboxane-insensitive dog platelets have impaired activation of phospholipase C due to receptor-linked G protein dysfunction.

Authors:  G J Johnson; L A Leis; P C Dunlop
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

7.  Stimulated cholesterol-enriched platelets display increased cytosolic Ca2+ and phospholipase A activity independent of changes in inositol trisphosphates and agonist/receptor binding.

Authors:  A Sorisky; G L Kucera; S E Rittenhouse
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857
  7 in total

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