Robert J Carrasquillo1,2, Taylor P Kohn3, Cengiz Cinnioglu4, Carmen Rubio5, Carlos Simon5, Ranjith Ramasamy6, Nasser Al-Asmar5. 1. Division of Urology, Beth Israel Deaconess Medical Center, 145 Rosemary Street, C-1, Needham, MA, 02494, USA. rjcarras@gmail.com. 2. Igenomix, Valencia, Spain. rjcarras@gmail.com. 3. Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA. 4. Igenomix USA, Los Angeles, CA, USA. 5. Igenomix, Valencia, Spain. 6. Department of Urology, University of Miami Health System, Miami, FL, USA.
Abstract
PURPOSE: To study the impact of advanced paternal age on embryo aneuploidy. METHODS: This is a multicenter international retrospective case series of couples undergoing assisted reproduction via in vitro fertilization using donor eggs to control for maternal factors and preimplantation genetic testing for aneuploidy via next-generation sequencing at Igenomix reproductive testing centers. The main outcome measure was the prevalence of embryo aneuploidy in egg donor cycles. Semen analysis data was retrieved for a small subset of the male patients. RESULTS: Data from 1202 IVF/ICSI egg donor cycles using ejaculated sperm (total 6934 embryos) evaluated using PGT-A between January 2016 and April 2018 in a global population across all Igenomix centers were included. No significant association was identified between advancing paternal age and the prevalence of embryo aneuploidy overall and when analyzing for each chromosome. There was also no significant association between advancing paternal age and specific aneuploid conditions (monosomy, trisomy, partial deletion/duplication) for all chromosomes in the genome. CONCLUSIONS: This is the largest study of its kind in an international patient population to evaluate the impact of advancing paternal age on embryo aneuploidy. We conclude there is no specific effect of paternal age on the prevalence of embryo aneuploidy in the context of embryo biopsies from egg donor cycles.
PURPOSE: To study the impact of advanced paternal age on embryo aneuploidy. METHODS: This is a multicenter international retrospective case series of couples undergoing assisted reproduction via in vitro fertilization using donor eggs to control for maternal factors and preimplantation genetic testing for aneuploidy via next-generation sequencing at Igenomix reproductive testing centers. The main outcome measure was the prevalence of embryo aneuploidy in egg donor cycles. Semen analysis data was retrieved for a small subset of the male patients. RESULTS: Data from 1202 IVF/ICSI egg donor cycles using ejaculated sperm (total 6934 embryos) evaluated using PGT-A between January 2016 and April 2018 in a global population across all Igenomix centers were included. No significant association was identified between advancing paternal age and the prevalence of embryo aneuploidy overall and when analyzing for each chromosome. There was also no significant association between advancing paternal age and specific aneuploid conditions (monosomy, trisomy, partial deletion/duplication) for all chromosomes in the genome. CONCLUSIONS: This is the largest study of its kind in an international patient population to evaluate the impact of advancing paternal age on embryo aneuploidy. We conclude there is no specific effect of paternal age on the prevalence of embryo aneuploidy in the context of embryo biopsies from egg donor cycles.
Authors: Linda Broer; Veryan Codd; Dale R Nyholt; Joris Deelen; Massimo Mangino; Gonneke Willemsen; Eva Albrecht; Najaf Amin; Marian Beekman; Eco J C de Geus; Anjali Henders; Christopher P Nelson; Claire J Steves; Margie J Wright; Anton J M de Craen; Aaron Isaacs; Mary Matthews; Alireza Moayyeri; Grant W Montgomery; Ben A Oostra; Jacqueline M Vink; Tim D Spector; P Eline Slagboom; Nicholas G Martin; Nilesh J Samani; Cornelia M van Duijn; Dorret I Boomsma Journal: Eur J Hum Genet Date: 2013-01-16 Impact factor: 4.246
Authors: Henry A Feldman; Christopher Longcope; Carol A Derby; Catherine B Johannes; Andre B Araujo; Andrea D Coviello; William J Bremner; John B McKinlay Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958
Authors: Maria Buhl Borgstrøm; Marie Louise Grøndahl; Tobias W Klausen; Anne K Danielsen; Thordis Thomsen; Ursula Bentin-Ley; Ulla B Knudsen; Steen Laursen; Morten R Petersen; Katrine Haahr; Karsten Petersen; Josephine G Lemmen; Johnny Hindkjær; John Kirk; Jens Fedder; Gitte J Almind; Christina Hnida; Bettina Troest; Betina B Povlsen; Anne Zedeler; Anette Gabrielsen; Thomas Larsen; Ulrik S Kesmodel Journal: PLoS One Date: 2022-07-28 Impact factor: 3.752
Authors: João Paolo Bilibio; Pânila Longhi Lorenzzoni; Brenda Mendes de Oliveira; Flora Leal Nascimento; Arivaldo José Conceição Meireles; Fábio Costa do Nascimento Journal: JBRA Assist Reprod Date: 2022-04-17