Nicole O McPherson1,2,3, Deirdre Zander-Fox4,5,6, Andrew D Vincent7, Michelle Lane4,7,6. 1. School of Medicine, Robinson Research Institute, Discipline of Obstetrics and Gynaecology, University of Adelaide, Level 3 Medical School South, Adelaide, South Australia, 5005, Australia. nicole.mcpherson@adelaide.edu.au. 2. Repromed, Dulwich, Adelaide, South Australia, 5065, Australia. nicole.mcpherson@adelaide.edu.au. 3. Freemasons Centre for Men's Health, University of Adelaide, Adelaide, South Australia, 5005, Australia. nicole.mcpherson@adelaide.edu.au. 4. School of Medicine, Robinson Research Institute, Discipline of Obstetrics and Gynaecology, University of Adelaide, Level 3 Medical School South, Adelaide, South Australia, 5005, Australia. 5. Repromed, Dulwich, Adelaide, South Australia, 5065, Australia. 6. Monash IVF Group, Richmond, Victoria, 3121, Australia. 7. Freemasons Centre for Men's Health, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Abstract
PURPOSE: The purpose of this study is to determine if there is an additive effect of combined advanced maternal and paternal age on pregnancy and live birth rates. METHODS: Retrospective data analysis of 4057 first cycles at a fertility centre between 2009 and 2013 was compiled. Donor, preimplantation genetic screening and double embryo transfer cycles were excluded. Main outcomes measured were clinical pregnancy, viable pregnancy, live birth and term birth. RESULTS: Logistic regression indicated strong negative associations for maternal ages exceeding 27 years with clinical pregnancies (p < 0.001), viable pregnancies (p < 0.001), live births (p < 0.001) and term births (p < 0.001). There was evidence of negative associations between paternal age and both viable pregnancies (p = 0.06) and live births (p = 0.04), such that the probability of pregnancy was 10% further reduced for women who were 35 years with a partner over 40 years vs. women aged 35 years with a partner under 30 years. There was evidence of an interaction between maternal age and the paternal age on term births (p = 0.02) such that advanced paternal age's effect on the probability of a term birth was only evident in couples where the maternal age ranged between ~27 and 35 years. CONCLUSIONS: There is an additive effect to pregnancy and live birth rates when both partners are of an advanced age, thus highlighting the need for pre-conception public health messaging and a combined approach to ART counselling assessing both parental ages in combination.
PURPOSE: The purpose of this study is to determine if there is an additive effect of combined advanced maternal and paternal age on pregnancy and live birth rates. METHODS: Retrospective data analysis of 4057 first cycles at a fertility centre between 2009 and 2013 was compiled. Donor, preimplantation genetic screening and double embryo transfer cycles were excluded. Main outcomes measured were clinical pregnancy, viable pregnancy, live birth and term birth. RESULTS: Logistic regression indicated strong negative associations for maternal ages exceeding 27 years with clinical pregnancies (p < 0.001), viable pregnancies (p < 0.001), live births (p < 0.001) and term births (p < 0.001). There was evidence of negative associations between paternal age and both viable pregnancies (p = 0.06) and live births (p = 0.04), such that the probability of pregnancy was 10% further reduced for women who were 35 years with a partner over 40 years vs. women aged 35 years with a partner under 30 years. There was evidence of an interaction between maternal age and the paternal age on term births (p = 0.02) such that advanced paternal age's effect on the probability of a term birth was only evident in couples where the maternal age ranged between ~27 and 35 years. CONCLUSIONS: There is an additive effect to pregnancy and live birth rates when both partners are of an advanced age, thus highlighting the need for pre-conception public health messaging and a combined approach to ART counselling assessing both parental ages in combination.
Authors: T E Schmid; B Eskenazi; A Baumgartner; F Marchetti; S Young; R Weldon; D Anderson; A J Wyrobek Journal: Hum Reprod Date: 2006-10-19 Impact factor: 6.918
Authors: Toshio Hamatani; Geppino Falco; Mark G Carter; Hidenori Akutsu; Carole A Stagg; Alexei A Sharov; Dawood B Dudekula; Vincent VanBuren; Minoru S H Ko Journal: Hum Mol Genet Date: 2004-08-18 Impact factor: 6.150