Literature DB >> 3137936

Inhibition of in vitro angiogenesis by lymphotoxin and interferon-gamma.

N Tsuruoka1, M Sugiyama, Y Tawaragi, M Tsujimoto, T Nishihara, T Goto, N Sato.   

Abstract

The effects of lymphotoxin (LT) and interferon (IFN)-gamma on the capillary formation was examined using an in vitro angiogenesis model system. Both LT and IFN-gamma inhibited the capillary formation in a dose dependent manner. To elucidate the mode of action, effects of the lymphokines on endothelial and myofibroblastic cells were studied. We found that the lymphokines inhibited not only the growth of endothelial cells but also the production of collagen by myofibroblastic cells. These results suggest that the pleiotropic effects of the lymphokines on different types of cells might result in the inhibition of the capillary formation.

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Year:  1988        PMID： 3137936     DOI： 10.1016/s0006-291x(88)81104-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

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5.  Effects of interferon-gamma on primary cultures of human brain microvessel endothelial cells.

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6.  Bovine microvascular endothelial cells of separate morphology differ in growth and response to the action of interferon-gamma.

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Review 7.  The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression.

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8.  IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells.

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Authors:  D A Arenberg; S L Kunkel; P J Polverini; S B Morris; M D Burdick; M C Glass; D T Taub; M D Iannettoni; R I Whyte; R M Strieter
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10.  Angiogenesis in a human neuroblastoma xenograft model: mechanisms and inhibition by tumour-derived interferon-gamma.

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