Literature DB >> 3137599

Effects of lorazepam on memory, attention and sedation in man.

G C Preston1, P Broks, M Traub, C Ward, P Poppleton, S M Stahl.   

Abstract

The effects of three doses of lorazepam (0.5, 1.0 and 2.0 mg PO) on various aspects of memory, attention and sedation are described. Lorazepam produced dose-related deficits in verbal secondary memory, choice reaction time and a novel vigilance task. It also produced a dose-dependent increase in subjective sedation, and an enhancement of visual contrast sensitivity. These results are compared with those reported earlier using the muscarinic antagonist scopolamine, and discussed in relation to models of Alzheimer's disease.

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Year:  1988        PMID： 3137599     DOI： 10.1007/bf00174511

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  24 in total

1.  Models of memory dysfunctions.

Authors:  H Weingartner
Journal:  Ann N Y Acad Sci       Date:  1985       Impact factor: 5.691

2.  Differences between fingers and hands in tapping ability: dissociation between speed and regularity.

Authors:  I C McManus; R I Kemp; J Grant
Journal:  Cortex       Date:  1986-09       Impact factor: 4.027

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Journal:  J Exp Psychol       Date:  1968-01

4.  The influence of GABAergic inhibitory processes on the receptive field structure of X and Y cells in cat dorsal lateral geniculate nucleus (dLGN).

Authors:  A M Sillito; J A Kemp
Journal:  Brain Res       Date:  1983-10-24       Impact factor: 3.252

5.  Selective loss of central cholinergic neurons in Alzheimer's disease.

Authors:  P Davies; A J Maloney
Journal:  Lancet       Date:  1976-12-25       Impact factor: 79.321

6.  Selective attention and priming: inhibitory and facilitatory effects of ignored primes.

Authors:  S P Tipper; M Cranston
Journal:  Q J Exp Psychol A       Date:  1985-11

7.  The nature of lorazepam-induced amnesia.

Authors:  R G Lister; S E File
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

8.  The effects of low doses of amylobarbitone sodium and diazepam on human performance.

Authors:  J Hart; H M Hill; C E Bye; R T Wilkinson; A W Peck
Journal:  Br J Clin Pharmacol       Date:  1976-04       Impact factor: 4.335

9.  Impaired performance and sedation after a single dose of lorazepam.

Authors:  S E File; A J Bond
Journal:  Psychopharmacology (Berl)       Date:  1979       Impact factor: 4.530

10.  Modelling dementia: effects of scopolamine on memory and attention.

Authors:  P Broks; G C Preston; M Traub; P Poppleton; C Ward; S M Stahl
Journal:  Neuropsychologia       Date:  1988       Impact factor: 3.139
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  22 in total

1.  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. I: Lorazepam.

Authors:  S K Gupta; E H Ellinwood; A M Nikaido; D G Heatherly
Journal:  J Pharmacokinet Biopharm       Date:  1990-04

2.  Behavioral analysis of diazepam-induced memory deficits: evidence for sedation-like effects.

Authors:  L E Kalynchuk; C H Beck
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  Scopolamine and benzodiazepine models of dementia: cross-reversals by Ro 15-1788 and physostigmine.

Authors:  G C Preston; C Ward; C R Lines; P Poppleton; J R Haigh; M Traub
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

4.  Effects of lorazepam on memory, attention and sedation in man: antagonism by Ro 15-1788.

Authors:  G C Preston; C E Ward; P Broks; M Traub; S M Stahl
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

5.  A study to evaluate the effect of ondansetron on psychomotor performance after repeated oral dosing in healthy subjects.

Authors:  S T Hall; P R Ceuppens
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

6.  Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia.

Authors:  N Cutler; J Sramek; A Veroff; G Block; L Stauffer; C Lines
Journal:  Br J Clin Pharmacol       Date:  1995-03       Impact factor: 4.335

7.  A comparison of the amnesic effects of lorazepam in alcoholics and non-alcoholics.

Authors:  J L Mallick; K C Kirkby; F Martin; M Philp; M J Hennessy
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  A comparison of the effect of lorazepam on memory in heavy and low social drinkers.

Authors:  J M Nichols; F Martin; K C Kirkby
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers.

Authors:  A Patat; M C Perault; B Vandel; N Ulliac; I Zieleniuk; P Rosenzweig
Journal:  Br J Clin Pharmacol       Date:  1995-01       Impact factor: 4.335

10.  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. II. Triazolam.

Authors:  S K Gupta; E H Ellinwood; A M Nikaido; D G Heatherly
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200
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