| Literature DB >> 31375416 |
Alexandre de Souza E Silva1, Adriana Pertille2, Carolina Gabriela Reis Barbosa2, Jasiele Aparecida de Oliveira Silva3, Diego Vilela de Jesus4, Anna Gabriela Silva Vilela Ribeiro2, Ronaldo Júlio Baganha4, José Jonas de Oliveira5.
Abstract
Creatine supplements are intended to improve performance, but there are indications that it can overwhelm liver and kidney functions, reduce the quality of life, and increase mortality. Therefore, this is the first systematic review and meta-analysis study that aimed to investigate creatine supplements and their possible renal function side effects. After evaluating 290 non-duplicated studies, 15 were included in the qualitative analysis and 6 in the quantitative analysis. The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.Entities:
Year: 2019 PMID： 31375416 DOI： 10.1053/j.jrn.2019.05.004
Source DB: PubMed Journal: J Ren Nutr ISSN： 1051-2276 Impact factor: 3.655