Literature DB >> 33557850

Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?

Jose Antonio1, Darren G Candow2, Scott C Forbes3, Bruno Gualano4, Andrew R Jagim5, Richard B Kreider6, Eric S Rawson7, Abbie E Smith-Ryan8, Trisha A VanDusseldorp9, Darryn S Willoughby10, Tim N Ziegenfuss11.   

Abstract

Supplementing with creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery. Accumulating evidence also suggests that creatine supplementation produces a variety of beneficial effects in older and patient populations. Furthermore, evidence-based research shows that creatine supplementation is relatively well tolerated, especially at recommended dosages (i.e. 3-5 g/day or 0.1 g/kg of body mass/day). Although there are over 500 peer-refereed publications involving creatine supplementation, it is somewhat surprising that questions regarding the efficacy and safety of creatine still remain. These include, but are not limited to: 1. Does creatine lead to water retention? 2. Is creatine an anabolic steroid? 3. Does creatine cause kidney damage/renal dysfunction? 4. Does creatine cause hair loss / baldness? 5. Does creatine lead to dehydration and muscle cramping? 6. Is creatine harmful for children and adolescents? 7. Does creatine increase fat mass? 8. Is a creatine 'loading-phase' required? 9. Is creatine beneficial for older adults? 10. Is creatine only useful for resistance / power type activities? 11. Is creatine only effective for males? 12. Are other forms of creatine similar or superior to monohydrate and is creatine stable in solutions/beverages? To answer these questions, an internationally renowned team of research experts was formed to perform an evidence-based scientific evaluation of the literature regarding creatine supplementation.

Entities:  

Keywords:  Adverse Effects; Anecdotal; Research; Safety; Social Media

Mesh:

Substances:

Year:  2021        PMID: 33557850      PMCID: PMC7871530          DOI: 10.1186/s12970-021-00412-w

Source DB:  PubMed          Journal:  J Int Soc Sports Nutr        ISSN: 1550-2783            Impact factor:   5.150


  181 in total

Review 1.  Androgen Receptor Structure, Function and Biology: From Bench to Bedside.

Authors:  Rachel A Davey; Mathis Grossmann
Journal:  Clin Biochem Rev       Date:  2016-02

2.  Renal dysfunction accompanying oral creatine supplements.

Authors:  P Greenhaff
Journal:  Lancet       Date:  1998-07-18       Impact factor: 79.321

3.  Long-term creatine intake is beneficial to muscle performance during resistance training.

Authors:  K Vandenberghe; M Goris; P Van Hecke; M Van Leemputte; L Vangerven; P Hespel
Journal:  J Appl Physiol (1985)       Date:  1997-12

4.  Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women.

Authors:  Philip D Chilibeck; Darren G Candow; Tim Landeryou; Mojtaba Kaviani; Lisa Paus-Jenssen
Journal:  Med Sci Sports Exerc       Date:  2015-08       Impact factor: 5.411

5.  Dietary supplement creatine protects against traumatic brain injury.

Authors:  P G Sullivan; J D Geiger; M P Mattson; S W Scheff
Journal:  Ann Neurol       Date:  2000-11       Impact factor: 10.422

6.  Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans.

Authors:  P Hespel; B Op't Eijnde; M Van Leemputte; B Ursø; P L Greenhaff; V Labarque; S Dymarkowski; P Van Hecke; E A Richter
Journal:  J Physiol       Date:  2001-10-15       Impact factor: 5.182

Review 7.  Creatine supplementation and aging musculoskeletal health.

Authors:  Darren G Candow; Philip D Chilibeck; Scott C Forbes
Journal:  Endocrine       Date:  2013-11-05       Impact factor: 3.633

Review 8.  Beyond muscles: The untapped potential of creatine.

Authors:  Lisa A Riesberg; Stephanie A Weed; Thomas L McDonald; Joan M Eckerson; Kristen M Drescher
Journal:  Int Immunopharmacol       Date:  2016-01-08       Impact factor: 4.932

9.  Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.

Authors:  Shan Zhu; Mingwei Li; Bryan E Figueroa; Aijian Liu; Irina G Stavrovskaya; Piera Pasinelli; M Flint Beal; Robert H Brown; Bruce S Kristal; Robert J Ferrante; Robert M Friedlander
Journal:  J Neurosci       Date:  2004-06-30       Impact factor: 6.167

Review 10.  Creatine Use in Sports.

Authors:  Jessica Butts; Bret Jacobs; Matthew Silvis
Journal:  Sports Health       Date:  2017-10-23       Impact factor: 3.843

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  14 in total

Review 1.  Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review.

Authors:  Richard B Kreider; Ralf Jäger; Martin Purpura
Journal:  Nutrients       Date:  2022-02-28       Impact factor: 5.717

2.  Transcriptomics combined with metabolomics analysis of the mechanism of agmatine in the treatment of septic liver injury.

Authors:  Ling Huang; Lianfang Gan; Junhua Pan; Lifan Zhong; Qianru Wang; Shanjun Luo; Jia Tian; Huaping Liang
Journal:  Ann Transl Med       Date:  2022-05

3.  Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study.

Authors:  Marek Kruszewski; Maciej Merchelski; Artur Kruszewski; Rafał Tabęcki; Maksim Olegovich Aksenov; Łukasz Pągowski
Journal:  Nutrients       Date:  2022-04-22       Impact factor: 6.706

4.  Side effects of amino acid supplements.

Authors:  M Holeček
Journal:  Physiol Res       Date:  2022-01-19       Impact factor: 1.881

Review 5.  Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults.

Authors:  Scott C Forbes; Darren G Candow; Sergej M Ostojic; Michael D Roberts; Philip D Chilibeck
Journal:  Nutrients       Date:  2021-06-02       Impact factor: 5.717

Review 6.  Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review.

Authors:  Diego A Bonilla; Richard B Kreider; Jeffrey R Stout; Diego A Forero; Chad M Kerksick; Michael D Roberts; Eric S Rawson
Journal:  Nutrients       Date:  2021-04-09       Impact factor: 5.717

Review 7.  Creatine Supplementation in Children and Adolescents.

Authors:  Andrew R Jagim; Chad M Kerksick
Journal:  Nutrients       Date:  2021-02-18       Impact factor: 5.717

8.  Morning versus Evening Intake of Creatine in Elite Female Handball Players.

Authors:  Jose Manuel Jurado-Castro; Julián Campos-Pérez; M Ángeles Vilches-Redondo; Fernando Mata; Ainoa Navarrete-Pérez; Antonio Ranchal-Sanchez
Journal:  Int J Environ Res Public Health       Date:  2021-12-30       Impact factor: 3.390

Review 9.  Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations.

Authors:  Benjamin Wax; Chad M Kerksick; Andrew R Jagim; Jerry J Mayo; Brian C Lyons; Richard B Kreider
Journal:  Nutrients       Date:  2021-06-02       Impact factor: 5.717

10.  Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats.

Authors:  Meline Gomes Gonçalves; Matheus Anselmo Medeiros; Licyanne Ingrid Carvalho de Lemos; Lucia de Fátima Campos Pedrosa; Pedro Paulo de Andrade Santos; Bento João Abreu; João Paulo Matos Santos Lima
Journal:  Nutrients       Date:  2022-01-19       Impact factor: 5.717

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