Literature DB >> 3137356

Template-directed oligomerization of 3-isoadenosine 5'-phosphate.

A R Hill1, S Kumar, N J Leonard, L E Orgel.   

Abstract

Template-directed oligomerization of an activated derivative of 3-isoadenosine 5'-phosphate (piA) on polyuridylic acid [poly(U)] was studied. The reaction of ImpiA is more efficient than the corresponding reaction of ImpA, and produces 3'-5'-linked oligomers while the reaction of ImpA gives only 2'-5'-linked oligomers. The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.

Entities:  

Keywords:  NASA Discipline Exobiology; Non-NASA Center

Mesh：

Substances：

Year:  1988        PMID： 3137356     DOI： 10.1007/bf02138366

Source DB:  PubMed          Journal:  J Mol Evol        ISSN： 0022-2844            Impact factor:   2.395


  8 in total

1.  Template-directed synthesis of novel, nucleic acid-like structures.

Authors:  A W Schwartz; L E Orgel
Journal:  Science       Date:  1985-05-03       Impact factor: 47.728

2.  Relatives of Watson-Crick DNA, RNA cross sections.

Authors:  N J Leonard; K A Cruickshank; M P Groziak; G L Clauson; B Devadas
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

3.  The case for an ancestral genetic system involving simple analogues of the nucleotides.

Authors:  G F Joyce; A W Schwartz; S L Miller; L E Orgel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

Review 4.  RNA catalysis and the origins of life.

Authors:  L E Orgel
Journal:  J Theor Biol       Date:  1986-11-21       Impact factor: 2.691

5.  Oligomerization of activated derivatives of 3'-amino-3'-deoxyguanosine on poly(C) and poly(dC) templates.

Authors:  W S Zielinski; L E Orgel
Journal:  Nucleic Acids Res       Date:  1985-04-11       Impact factor: 16.971

6.  Polynucleotide analogues. VIII. Poly 3-isoadenylic acid.

Authors:  A M Michelson; C Monny; R A Laursen; N J Leonard
Journal:  Biochim Biophys Acta       Date:  1966-05-19

7.  Nucleic acid-like structures. III. Oligomerization of 3'-deoxyadenosine 2',5'-diphosphoimidazolide.

Authors:  J Visscher; A W Schwartz
Journal:  J Mol Evol       Date:  1987       Impact factor: 2.395

8.  Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.

Authors:  G F Joyce; T Inoue; L E Orgel
Journal:  J Mol Biol       Date:  1984-06-25       Impact factor: 5.469
  8 in total
  6 in total

1.  Chemical structure of a prebiotic analog of adenosine.

Authors:  M C Maurel; O Convert
Journal:  Orig Life Evol Biosph       Date:  1990       Impact factor: 1.950

2.  N6-substituted adenine derivatives and RNA primitive catalysts.

Authors:  J L Décout; M C Maurel
Journal:  Orig Life Evol Biosph       Date:  1993-12       Impact factor: 1.950

3.  Template-directed oligomerization of 5'-deoxy-5'-nucleosideacetic acid derivatives.

Authors:  K Harada; L E Orgel
Journal:  Orig Life Evol Biosph       Date:  1990       Impact factor: 1.950

4.  Attempted nonenzymatic template-directed oligomerizations on a polyadenylic acid template: implications for the nature of the first genetic material.

Authors:  R Stribling; S L Miller
Journal:  J Mol Evol       Date:  1991       Impact factor: 2.395

5.  Which 3-ribofuranosyl-substituted purine 5'-phosphates undergo template-directed oligomerization?

Authors:  A R Hill; S Kumar; V D Patil; N J Leonard; L E Orgel
Journal:  J Mol Evol       Date:  1991-06       Impact factor: 2.395

6.  Nonenzymatic synthesis of 5-aminoimidazole ribonucleoside and recognition of its facile rearrangement.

Authors:  M P Groziak; B Bhat; N J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205
  6 in total

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