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Literature DB >> 1651397

Which 3-ribofuranosyl-substituted purine 5'-phosphates undergo template-directed oligomerization?

A R Hill¹, S Kumar, V D Patil, N J Leonard, L E Orgel.

Abstract

We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5'-phosphate (2) and 3-isoxanthosine 5'-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic acid, polyadenylic acid, polyinosinic acid, and polyguanylic acid were ineffective as templates in the systems that we investigated.

Entities: Chemical

Mesh：

Substances：

Year: 1991 PMID： 1651397 DOI： 10.1007/bf02102646

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

17 in total

9. 3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES.

Authors: D HATFIELD; J B WYNGAARDEN
Journal: J Biol Chem Date: 1964-08 Impact factor: 5.157

10. Template-directed oligomerization of 3-isoadenosine 5'-phosphate.

Authors: A R Hill; S Kumar; N J Leonard; L E Orgel
Journal: J Mol Evol Date: 1988 Impact factor: 2.395

1 in total

1. Life in a ligand sphere.

Authors: G Wächtershäuser
Journal: Proc Natl Acad Sci U S A Date: 1994-05-10 Impact factor: 11.205

1 in total

Which 3-ribofuranosyl-substituted purine 5'-phosphates undergo template-directed oligomerization?

1. Template-directed synthesis of novel, nucleic acid-like structures.

2. Structure of 3-isoinosine.

3. Nonenzymatic template-directed synthesis of informational macromolecules.

4. The case for an ancestral genetic system involving simple analogues of the nucleotides.

Review 5. RNA catalysis and the origins of life.

6. Structure of 3-isoadenosine.

7. Interaction of polyadenylic acid with methylated xanthines.

8. Complexes of poly(adenylic acid) with complementary monomers.

9. 3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES.

10. Template-directed oligomerization of 3-isoadenosine 5'-phosphate.

1. Life in a ligand sphere.