| Literature DB >> 3137305 |
R L Medcalf1, E K Kruithof, W D Schleuning.
Abstract
Human rTNF/Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor (PA1)-1 and PAI-2, and simultaneously suppress constitutive gene expression of tissue-type plasminogen activator (t-PA) in human fibrosarcoma cells. We propose that a TNF-mediated reprogramming of gene transcription induces, in appropriate target cells, an anti-fibrinolytic state, which may cooperate with the induction of procoagulant activity (tissue factor) to stabilize the fibrin deposits commonly found in inflamed tissue. PAI genes also provide a model system for a study of the molecular pathways underlying TNF-mediated signal transduction.Entities:
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Year: 1988 PMID： 3137305 PMCID： PMC2188989 DOI： 10.1084/jem.168.2.751
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307