Literature DB >> 3137047

Antagonism of the direct fungicidal action of miconazole by miconazole fungistasis.

W H Beggs1, I R LaSota, C E Hughes.   

Abstract

A weakly fungistatic concentration of miconazole in lag phase yeast cultures of Candida albicans antagonized development of phenotypic susceptibility to the direct fungicidal action of high-level (i.e. greater than 10(-5) M) miconazole. After development in the absence of drug, maintenance of susceptibility upon continued incubation was also antagonized by low levels of miconazole. This auto-antagonistic effect has important clinical implications.

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Year:  1988        PMID： 3137047     DOI： 10.1007/bf01962351

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  8 in total

1.  Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans.

Authors:  H van den Bossche; G Willemsens; W Cools; W F Lauwers; L Le Jeune
Journal:  Chem Biol Interact       Date:  1978-04       Impact factor: 5.192

Review 2.  Mode of action of clinically important antifungal drugs.

Authors:  D Kerridge
Journal:  Adv Microb Physiol       Date:  1986       Impact factor: 3.517

3.  Role of pH in the lethal direct cell damaging action of miconazole.

Authors:  W H Beggs; C E Hughes
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1986-09

4.  Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles.

Authors:  H Van den Bossche; G Willemsens; W Cools; P Marichal; W Lauwers
Journal:  Biochem Soc Trans       Date:  1983-12       Impact factor: 5.407

5.  Action of fluconazole (UK-49,858) in relation to other systemic antifungal azoles.

Authors:  C E Hughes; W H Beggs
Journal:  J Antimicrob Chemother       Date:  1987-02       Impact factor: 5.790

6.  Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans.

Authors:  W H Beggs
Journal:  Antimicrob Agents Chemother       Date:  1984-03       Impact factor: 5.191

7.  The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans.

Authors:  C A Hitchcock; K J Barrett-Bee; N J Russell
Journal:  J Gen Microbiol       Date:  1986-09

8.  Mode of action of miconazole on Candida albicans: effect on growth, viability and K+ release.

Authors:  J E Cope
Journal:  J Gen Microbiol       Date:  1980-07
  8 in total
  2 in total

1.  Antagonisms of potential concern in the clinical use of antifungal imidazoles and related azole-type drugs.

Authors:  W H Beggs
Journal:  Mycopathologia       Date:  1992-12       Impact factor: 2.574

2.  Development of phenotypic resistance to direct lethal miconazole action by Candida albicans entering stationary phase.

Authors:  W H Beggs
Journal:  Mycopathologia       Date:  1989-12       Impact factor: 2.574
  2 in total

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