Action of fluconazole (UK-49,858) in relation to other systemic antifungal azoles.

Viability studies showed that fluconazole (UK-49,858) was strictly fungistatic in its activity against three strains of Candida species, whether tested against yeasts in stationary or early logarithmic phase. In this regard, fluconazole appears to offer no advantage over three other oral azole-containing agents, including ketoconazole, vibunazole (Bay n 7133), and ICI 153,066.