Katrina Abuabara1, Yue You2, David J Margolis3, Thomas J Hoffmann4, Neil Risch5, Eric Jorgenson6. 1. Program for Clinical Research, Department of Dermatology, University of California, San Francisco, Calif. Electronic address: Katrina.abuabara@ucsf.edu. 2. Division of Biostatistics and Epidemiology, University of California, Berkeley, Calif. 3. Department of Dermatology and Center for Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa. 4. Institute for Human Genetics and Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif. 5. Institute for Human Genetics and Department of Epidemiology and Biostatistics, University of California, San Francisco, Calif; Division of Research, Kaiser Permanente, Oakland, Calif. 6. Division of Research, Kaiser Permanente, Oakland, Calif.
Abstract
BACKGROUND: Atopic dermatitis (AD) is more common among African American children. Whether there are racial/ethnic difference among adults with AD and the causes for those disparities are unclear. OBJECTIVE: We sought to examine the relationship between self-reported race/ethnicity and AD and determine whether African genetic ancestry is predictive of these outcomes among African American subjects. METHODS: We analyzed data from 2 independent multiethnic longitudinal studies: 86,893 subjects aged 18 to 100 years from the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort and 5467 subjects aged 2 to 26 years from the national Pediatric Eczema Elective Registry (PEER) cohort. The primary outcomes were physician-diagnosed AD in GERA and repeated measures of self-reported disease control among patients with physician-diagnosed AD at 6-month intervals in PEER. We examined whether self-identified African American race/ethnicity was predictive of these outcomes and then tested whether a continuous measure of African genetic ancestry was associated with outcomes within the African American group. RESULTS: AD was more common among self-identified African American subjects than non-Hispanic white subjects in GERA (4.4% vs 2.1%; odds ratio, 2.06; 95% CI, 1.70-2.48) and less well-controlled in PEER subjects (odds of 1-level worse control, 1.91; 95% CI, 1.64-2.22). However, African genetic ancestry was not associated with AD risk or control among self-identified African American subjects in either cohort, nor did an AD polygenic risk score or genetic skin pigment score explain the AD disparities in patients with AD. CONCLUSION: Ancestry-related genetic effects do not explain increased AD prevalence or poorer disease control among African American subjects.
BACKGROUND: Atopic dermatitis (AD) is more common among African American children. Whether there are racial/ethnic difference among adults with AD and the causes for those disparities are unclear. OBJECTIVE: We sought to examine the relationship between self-reported race/ethnicity and AD and determine whether African genetic ancestry is predictive of these outcomes among African American subjects. METHODS: We analyzed data from 2 independent multiethnic longitudinal studies: 86,893 subjects aged 18 to 100 years from the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort and 5467 subjects aged 2 to 26 years from the national Pediatric Eczema Elective Registry (PEER) cohort. The primary outcomes were physician-diagnosed AD in GERA and repeated measures of self-reported disease control among patients with physician-diagnosed AD at 6-month intervals in PEER. We examined whether self-identified African American race/ethnicity was predictive of these outcomes and then tested whether a continuous measure of African genetic ancestry was associated with outcomes within the African American group. RESULTS: AD was more common among self-identified African American subjects than non-Hispanic white subjects in GERA (4.4% vs 2.1%; odds ratio, 2.06; 95% CI, 1.70-2.48) and less well-controlled in PEER subjects (odds of 1-level worse control, 1.91; 95% CI, 1.64-2.22). However, African genetic ancestry was not associated with AD risk or control among self-identified African American subjects in either cohort, nor did an AD polygenic risk score or genetic skin pigment score explain the AD disparities in patients with AD. CONCLUSION: Ancestry-related genetic effects do not explain increased AD prevalence or poorer disease control among African American subjects.
Authors: Rajesh Kumar; Max A Seibold; Melinda C Aldrich; L Keoki Williams; Alex P Reiner; Laura Colangelo; Joshua Galanter; Christopher Gignoux; Donglei Hu; Saunak Sen; Shweta Choudhry; Edward L Peterson; Jose Rodriguez-Santana; William Rodriguez-Cintron; Michael A Nalls; Tennille S Leak; Ellen O'Meara; Bernd Meibohm; Stephen B Kritchevsky; Rongling Li; Tamara B Harris; Deborah A Nickerson; Myriam Fornage; Paul Enright; Elad Ziv; Lewis J Smith; Kiang Liu; Esteban González Burchard Journal: N Engl J Med Date: 2010-07-07 Impact factor: 91.245
Authors: Mark N Kvale; Stephanie Hesselson; Thomas J Hoffmann; Yang Cao; David Chan; Sheryl Connell; Lisa A Croen; Brad P Dispensa; Jasmin Eshragh; Andrea Finn; Jeremy Gollub; Carlos Iribarren; Eric Jorgenson; Lawrence H Kushi; Richard Lao; Yontao Lu; Dana Ludwig; Gurpreet K Mathauda; William B McGuire; Gangwu Mei; Sunita Miles; Michael Mittman; Mohini Patil; Charles P Quesenberry; Dilrini Ranatunga; Sarah Rowell; Marianne Sadler; Lori C Sakoda; Michael Shapero; Ling Shen; Tanu Shenoy; David Smethurst; Carol P Somkin; Stephen K Van Den Eeden; Lawrence Walter; Eunice Wan; Teresa Webster; Rachel A Whitmer; Simon Wong; Chia Zau; Yiping Zhan; Catherine Schaefer; Pui-Yan Kwok; Neil Risch Journal: Genetics Date: 2015-06-19 Impact factor: 4.562
Authors: Natalia Hernandez-Pacheco; Carlos Flores; Sam S Oh; Esteban G Burchard; Maria Pino-Yanes Journal: Curr Allergy Asthma Rep Date: 2016-07 Impact factor: 4.806
Authors: Mahboobeh Mahdavinia; Susan R Fox; Bridget M Smith; Christine James; Erica L Palmisano; Aisha Mohammed; Zeeshan Zahid; Amal H Assa'ad; Mary C Tobin; Ruchi S Gupta Journal: J Allergy Clin Immunol Pract Date: 2016-11-23
Authors: Yambazi Banda; Mark N Kvale; Thomas J Hoffmann; Stephanie E Hesselson; Dilrini Ranatunga; Hua Tang; Chiara Sabatti; Lisa A Croen; Brad P Dispensa; Mary Henderson; Carlos Iribarren; Eric Jorgenson; Lawrence H Kushi; Dana Ludwig; Diane Olberg; Charles P Quesenberry; Sarah Rowell; Marianne Sadler; Lori C Sakoda; Stanley Sciortino; Ling Shen; David Smethurst; Carol P Somkin; Stephen K Van Den Eeden; Lawrence Walter; Rachel A Whitmer; Pui-Yan Kwok; Catherine Schaefer; Neil Risch Journal: Genetics Date: 2015-06-19 Impact factor: 4.562
Authors: Lavinia Paternoster; Marie Standl; Johannes Waage; Hansjörg Baurecht; Melanie Hotze; David P Strachan; John A Curtin; Klaus Bønnelykke; Chao Tian; Atsushi Takahashi; Jorge Esparza-Gordillo; Alexessander Couto Alves; Jacob P Thyssen; Herman T den Dekker; Manuel A Ferreira; Elisabeth Altmaier; Patrick Ma Sleiman; Feng Li Xiao; Juan R Gonzalez; Ingo Marenholz; Birgit Kalb; Maria Pino Yanes; Cheng-Jian Xu; Lisbeth Carstensen; Maria M Groen-Blokhuis; Cristina Venturini; Craig E Pennell; Sheila J Barton; Albert M Levin; Ivan Curjuric; Mariona Bustamante; Eskil Kreiner-Møller; Gabrielle A Lockett; Jonas Bacelis; Supinda Bunyavanich; Rachel A Myers; Anja Matanovic; Ashish Kumar; Joyce Y Tung; Tomomitsu Hirota; Michiaki Kubo; Wendy L McArdle; A J Henderson; John P Kemp; Jie Zheng; George Davey Smith; Franz Rüschendorf; Anja Bauerfeind; Min Ae Lee-Kirsch; Andreas Arnold; Georg Homuth; Carsten O Schmidt; Elisabeth Mangold; Sven Cichon; Thomas Keil; Elke Rodríguez; Annette Peters; Andre Franke; Wolfgang Lieb; Natalija Novak; Regina Fölster-Holst; Momoko Horikoshi; Juha Pekkanen; Sylvain Sebert; Lise L Husemoen; Niels Grarup; Johan C de Jongste; Fernando Rivadeneira; Albert Hofman; Vincent Wv Jaddoe; Suzanne Gma Pasmans; Niels J Elbert; André G Uitterlinden; Guy B Marks; Philip J Thompson; Melanie C Matheson; Colin F Robertson; Janina S Ried; Jin Li; Xian Bo Zuo; Xiao Dong Zheng; Xian Yong Yin; Liang Dan Sun; Maeve A McAleer; Grainne M O'Regan; Caoimhe Mr Fahy; Linda E Campbell; Milan Macek; Michael Kurek; Donglei Hu; Celeste Eng; Dirkje S Postma; Bjarke Feenstra; Frank Geller; Jouke Jan Hottenga; Christel M Middeldorp; Pirro Hysi; Veronique Bataille; Tim Spector; Carla Mt Tiesler; Elisabeth Thiering; Badri Pahukasahasram; James J Yang; Medea Imboden; Scott Huntsman; Natàlia Vilor-Tejedor; Caroline L Relton; Ronny Myhre; Wenche Nystad; Adnan Custovic; Scott T Weiss; Deborah A Meyers; Cilla Söderhäll; Erik Melén; Carole Ober; Benjamin A Raby; Angela Simpson; Bo Jacobsson; John W Holloway; Hans Bisgaard; Jordi Sunyer; Nicole M Probst Hensch; L Keoki Williams; Keith M Godfrey; Carol A Wang; Dorret I Boomsma; Mads Melbye; Gerard H Koppelman; Deborah Jarvis; Wh Irwin McLean; Alan D Irvine; Xue Jun Zhang; Hakon Hakonarson; Christian Gieger; Esteban G Burchard; Nicholas G Martin; Liesbeth Duijts; Allan Linneberg; Marjo-Riitta Jarvelin; Markus M Noethen; Susanne Lau; Norbert Hübner; Young-Ae Lee; Mayumi Tamari; David A Hinds; Daniel Glass; Sara J Brown; Joachim Heinrich; David M Evans; Stephan Weidinger Journal: Nat Genet Date: 2015-10-19 Impact factor: 38.330
Authors: Taylor A Jamerson; Qinmengge Li; Sutharzan Sreeskandarajan; Irina V Budunova; Zhi He; Jian Kang; Johann E Gudjonsson; Matthew T Patrick; Lam C Tsoi Journal: Front Immunol Date: 2022-04-28 Impact factor: 8.786
Authors: Carolyn Lou; Nandita Mitra; Bradley Wubbenhorst; Kurt D'Andrea; Ole Hoffstad; Brian S Kim; Albert Yan; Andrea L Zaenglein; Zelma Chiesa Fuxench; Katherine L Nathanson; David J Margolis Journal: Ann Allergy Asthma Immunol Date: 2019-09-04 Impact factor: 6.347