A'sha Brown1, Sara V Branson2, Ghazala A Datoo O'Keefe3. 1. Emory University School of Medicine, Emory Eye Center, Medical Retinal and Uveitis Fellow, Atlanta, Georgia, USA. 2. Emory University School of Medicine, Emory Eye Center, Resident, Atlanta, Georgia, USA. 3. Emory University School of Medicine, Assistant Professor of Ophthalmology, Section of Vitreoretinal Surgery and Diseases, Section of Uveitis and Vasculitis, Atlanta, Georgia, USA.
Abstract
BACKGROUND/AIMS: To report a case of a 65-year-old female who presented with bilateral anterior granulomatous uveitis, which led to the diagnosis of Rosai-Dorfman Disease (RDD) and the discovery of an associated pancreatic mass. METHODS: This is a retrospective case report of a single patient. RESULTS: A 65-year-old African American Female received a full workup for bilateral anterior granulomatous uveitis and was found to have a pancreatic mass on imaging. Biopsy of this mass was diagnostic for RDD, a rare proliferative histiocytic disorder, which classically presents with painless cervical lymphadenopathy, leukocytosis, and hypergammaglobulinemia. CONCLUSION: Although rare, ocular involvement, including eyelid and orbital masses, and anterior uveitis, can herald the development of other systemic manifestations or RDD and can aid in the diagnosis of this systemic disease.
BACKGROUND/AIMS: To report a case of a 65-year-old female who presented with bilateral anterior granulomatous uveitis, which led to the diagnosis of Rosai-Dorfman Disease (RDD) and the discovery of an associated pancreatic mass. METHODS: This is a retrospective case report of a single patient. RESULTS: A 65-year-old African American Female received a full workup for bilateral anterior granulomatous uveitis and was found to have a pancreatic mass on imaging. Biopsy of this mass was diagnostic for RDD, a rare proliferative histiocytic disorder, which classically presents with painless cervical lymphadenopathy, leukocytosis, and hypergammaglobulinemia. CONCLUSION: Although rare, ocular involvement, including eyelid and orbital masses, and anterior uveitis, can herald the development of other systemic manifestations or RDD and can aid in the diagnosis of this systemic disease.
Authors: Juan G Gaviria; Daniel A Johnson; Marsha C Kinney; Liana H Proffer; Jacqueline M Losi-Sasaki; Eric W Kraus Journal: Graefes Arch Clin Exp Ophthalmol Date: 2004-09-30 Impact factor: 3.117