Suvi Sirkku Tuohinen1,2, Tanja Skytta3,4, Heini Huhtala5, Vesa Virtanen2, Pirkko-Liisa Kellokumpu-Lehtinen3,4, Pekka Raatikainen6. 1. Heart and Lung Center, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland suvi.tuohinen@fimnet.fi. 2. Faculty of Medicine and Life Sciences, Tampere University Hospital, University of Tampere and Heart Center, Tampere, Finland. 3. Department of Oncology, Tampere University Hospital, Tampere, Finland. 4. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 5. Faculty of Social Sciences, University of Tampere, Tampere, Finland. 6. Heart and Lung Center, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland.
Abstract
BACKGROUND/AIM: Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. MATERIALS AND METHODS: This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who were evaluated at baseline, immediately after RT and three years after RT. Sixty-one patients had left-sided (LSBC) and 20 right-sided breast cancer (RSBC). RESULTS: Global longitudinal strain (GLS) declined from baseline -18.0±3.3% to -17.0±3.0% (p=0.015) at the three-year follow-up examination. A decline over 15% (GLS15) was observed in 19 (27%) patients. GLS15 was independently associated with aromatase inhibitor use (β=-1.977, p=0.001). In regional analysis, patients with LSBC had apical strain decline by 3.2±5.5% (p<0.001) and patients with RSBC showed basal rotation decline by 1.8° (-0.2°, 3.8°) (p=0.030). CONCLUSION: Even contemporary RT induced progressive global and regional decline in speckle tracking analysis. The regional changes complied with RT fields. Copyright
BACKGROUND/AIM: Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. MATERIALS AND METHODS: This prospective study included 81 chemotherapy-naïve early-stage breast cancerpatients who were evaluated at baseline, immediately after RT and three years after RT. Sixty-one patients had left-sided (LSBC) and 20 right-sided breast cancer (RSBC). RESULTS: Global longitudinal strain (GLS) declined from baseline -18.0±3.3% to -17.0±3.0% (p=0.015) at the three-year follow-up examination. A decline over 15% (GLS15) was observed in 19 (27%) patients. GLS15 was independently associated with aromatase inhibitor use (β=-1.977, p=0.001). In regional analysis, patients with LSBC had apical strain decline by 3.2±5.5% (p<0.001) and patients with RSBC showed basal rotation decline by 1.8° (-0.2°, 3.8°) (p=0.030). CONCLUSION: Even contemporary RT induced progressive global and regional decline in speckle tracking analysis. The regional changes complied with RT fields. Copyright
Authors: Elissa A S Polomski; Julius C Heemelaar; Augustinus D G Krol; Marloes Louwerens; Saskia L M A Beeres; Eduard R Holman; J Wouter Jukema; Martin J Schalij; M Louisa Antoni Journal: Cancers (Basel) Date: 2022-05-08 Impact factor: 6.575
Authors: Hanna Aula; Tanja Skyttä; Suvi Tuohinen; Tiina Luukkaala; Mari Hämäläinen; Vesa Virtanen; Pekka Raatikainen; Eeva Moilanen; Pirkko-Liisa Kellokumpu-Lehtinen Journal: Breast Date: 2019-12-06 Impact factor: 4.380