Literature DB >> 31364070

Polymyxins: Mode of Action.

Zhifeng Li1, Tony Velkov2.   

Abstract

The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development. This chapter provides a concise treatise of the current knowledge-based on the primary mode of action of polymyxins as well as recent developments in understanding of bacterial cell responses and secondary modes of action.

Entities:  

Keywords:  Free radical; LPS; Outer membrane remodelling; Polymyxin; Type II NADH-quinone oxidoreductase

Mesh：

Substances：

Year:  2019        PMID： 31364070     DOI： 10.1007/978-3-030-16373-0_4

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  7 in total

1.  Prevalence and Molecular Characteristics of Polymyxin-Resistant Pseudomonas aeruginosa in a Chinese Tertiary Teaching Hospital.

Authors:  Chenlu Xiao; Yan Zhu; Zhitao Yang; Dake Shi; Yuxing Ni; Li Hua; Jian Li
Journal:  Antibiotics (Basel)       Date:  2022-06-14

2.  Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane.

Authors:  Selen Manioglu; Seyed Majed Modaresi; Noah Ritzmann; Johannes Thoma; Sarah A Overall; Alexander Harms; Gregory Upert; Anatol Luther; Alexander B Barnes; Daniel Obrecht; Daniel J Müller; Sebastian Hiller
Journal:  Nat Commun       Date:  2022-10-21       Impact factor: 17.694

Review 3.  The microbiome-shaping roles of bacteriocins.

Authors:  Simon Heilbronner; Bernhard Krismer; Heike Brötz-Oesterhelt; Andreas Peschel
Journal:  Nat Rev Microbiol       Date:  2021-06-01       Impact factor: 60.633

4.  Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth.

Authors:  Emily C A Goodall; Georgia L Isom; Jessica L Rooke; Karthik Pullela; Christopher Icke; Zihao Yang; Gabriela Boelter; Alun Jones; Isabel Warner; Rochelle Da Costa; Bing Zhang; James Rae; Wee Boon Tan; Matthias Winkle; Antoine Delhaye; Eva Heinz; Jean-Francois Collet; Adam F Cunningham; Mark A Blaskovich; Robert G Parton; Jeff A Cole; Manuel Banzhaf; Shu-Sin Chng; Waldemar Vollmer; Jack A Bryant; Ian R Henderson
Journal:  PLoS Genet       Date:  2021-12-23       Impact factor: 5.917

5.  Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane.

Authors:  Akshay Sabnis; Katheryn Lh Hagart; Anna Klöckner; Michele Becce; Lindsay E Evans; R Christopher D Furniss; Despoina Ai Mavridou; Ronan Murphy; Molly M Stevens; Jane C Davies; Gérald J Larrouy-Maumus; Thomas B Clarke; Andrew M Edwards
Journal:  Elife       Date:  2021-04-06       Impact factor: 8.140

6.  A polytherapy based approach to combat antimicrobial resistance using cubosomes.

Authors:  Xiangfeng Lai; Mei-Ling Han; Yue Ding; Seong Hoong Chow; Anton P Le Brun; Chun-Ming Wu; Phillip J Bergen; Jhih-Hang Jiang; Hsien-Yi Hsu; Benjamin W Muir; Jacinta White; Jiangning Song; Jian Li; Hsin-Hui Shen
Journal:  Nat Commun       Date:  2022-01-17       Impact factor: 14.919

Review 7.  Polymer Conjugates of Antimicrobial Peptides (AMPs) with d-Amino Acids (d-aa): State of the Art and Future Opportunities.

Authors:  Ottavia Bellotto; Sabrina Semeraro; Antonella Bandiera; Federica Tramer; Nicola Pavan; Silvia Marchesan
Journal:  Pharmaceutics       Date:  2022-02-19       Impact factor: 6.321
  7 in total

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