Shihao Zhou 1 , Qiong Zhan 2 , Xiaomei Wu 2 Show Affiliations »
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OBJECTIVE: This study aimed to explore the clinical effect of levetiracetam in the treatment of children with epilepsy . METHODS: 136 children with epilepsy were selected from January 2017 to December 2017 . According to the random number table method, they were divided into the experimental group and the conventional group, with 68 cases in each group. The conventional group was treated with valproate , while the experimental group was treated with levetiracetam . The effective rate, the cognitive function and the frequency of clonic seizures in the two groups were compared. RESULTS: There was no significant difference in the total effective rate between the two groups (P>0.05). There was no significant difference in attention, executive ability, abstract and orientation scores between the two groups before treatment (P>0.05). After treatment, the focus of attention (106.54±6.56), executive ability (105.76±6.77), abstract and directional score (106.65±6.57) were significantly higher than that of the conventional group. The difference in the two groups was statistically significant (P<0.05). After 3 months of treatment, the frequency of myoclonic seizures (9.22±0.95) and the frequency of tonic-clonic seizures (11.68±1.36) were found to be significantly lower than those of the conventional group, and the difference between the two groups was statistically significant (P<0.05). CONCLUSION: Levetiracetam is effective in the treatment of children with epilepsy . It can effectively improve the cognitive function of the patients, reduce the frequency of myoclonic seizures and tonic-clonic seizures, and has a high promotion value. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
RCT Entities: Population
Interventions
Outcomes
OBJECTIVE: This study aimed to explore the clinical effect of levetiracetam in the treatment of children with epilepsy . METHODS: 136 children with epilepsy were selected from January 2017 to December 2017. According to the random number table method, they were divided into the experimental group and the conventional group, with 68 cases in each group. The conventional group was treated with valproate , while the experimental group was treated with levetiracetam . The effective rate, the cognitive function and the frequency of clonic seizures in the two groups were compared. RESULTS: There was no significant difference in the total effective rate between the two groups (P>0.05). There was no significant difference in attention, executive ability, abstract and orientation scores between the two groups before treatment (P>0.05). After treatment, the focus of attention (106.54±6.56), executive ability (105.76±6.77), abstract and directional score (106.65±6.57) were significantly higher than that of the conventional group. The difference in the two groups was statistically significant (P<0.05). After 3 months of treatment, the frequency of myoclonic seizures (9.22±0.95) and the frequency of tonic-clonic seizures (11.68±1.36) were found to be significantly lower than those of the conventional group, and the difference between the two groups was statistically significant (P<0.05). CONCLUSION: Levetiracetam is effective in the treatment of children with epilepsy . It can effectively improve the cognitive function of the patients , reduce the frequency of myoclonic seizures and tonic-clonic seizures , and has a high promotion value. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Species
Keywords:
Epilepsy; clonic seizure; cognitive function; levetiracetam; myoclonic seizures.
Year: 2019
PMID： 31362674 DOI： 10.2174/1566524019666190729113321
Source DB: PubMed Journal: Curr Mol Med ISSN： 1566-5240 Impact factor: 2.222