| Literature DB >> 31362044 |
Spyros S Skandalis1, Theodoros T Karalis2, Athanasios Chatzopoulos2, Nikos K Karamanos2.
Abstract
The prominent role of CD44 in tumor cell signaling together with its establishment as a cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC functional properties. Hyaluronan, the main ligand of CD44, is a major constituent of CSC niche and, therefore, the hyaluronan-CD44 signaling axis is of functional importance in this special microenvironment. This review aims to provide recent advances in the importance of hyaluronan-CD44 interactions in the acquisition and maintenance of a CSC phenotype. Hyaluronan-CD44 axis has a substantial impact on stemness properties of CSCs and drug resistance through induction of EMT program, oxidative stress resistance, secretion of extracellular vesicles/exosomes and epigenetic control. Potential therapeutic approaches targeting CSCs based on the hyaluronan-CD44 axis are also presented.Entities:
Keywords: CD44; Cancer niche; Cancer stem cells (CSCs); Drug resistance; EMT; Exosomes; Hyaluronan
Year: 2019 PMID： 31362044 DOI： 10.1016/j.cellsig.2019.109377
Source DB: PubMed Journal: Cell Signal ISSN： 0898-6568 Impact factor: 4.315