LaDeidra Monet Roberts1, Jennifer Munson1. 1. Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Abstract
PURPOSE OF REVIEW: This review focuses on the development and progression of glioblastoma through the brain and glioma microenvironment. Specifically we highlight how the tumor microenvironment contributes to the hallmarks of cancer in hopes of offering novel therapeutic options and tools to target this microenvironment. RECENT FINDINGS: The hallmarks of cancer, which represent elements of cancers that contribute to the disease's malignancy, yet elements within the brain tumor microenvironment, such as other cellular types as well as biochemical and biophysical cues that can each uniquely affect tumor cells, have not been well-described in this context and serve as potential targets for modulation. SUMMARY: Here, we highlight how the brain tumor microenvironment contributes to the progression and therapeutic response of tumor cells. Specifically, we examine these contributions through the lens of Hanahan & Weinberg's Hallmarks of Cancer in order to identify potential novel targets within the brain that may offer a means to treat brain cancers, including the deadliest brain cancer, glioblastoma.
PURPOSE OF REVIEW: This review focuses on the development and progression of glioblastoma through the brain and glioma microenvironment. Specifically we highlight how the tumor microenvironment contributes to the hallmarks of cancer in hopes of offering novel therapeutic options and tools to target this microenvironment. RECENT FINDINGS: The hallmarks of cancer, which represent elements of cancers that contribute to the disease's malignancy, yet elements within the brain tumor microenvironment, such as other cellular types as well as biochemical and biophysical cues that can each uniquely affect tumor cells, have not been well-described in this context and serve as potential targets for modulation. SUMMARY: Here, we highlight how the brain tumor microenvironment contributes to the progression and therapeutic response of tumor cells. Specifically, we examine these contributions through the lens of Hanahan & Weinberg's Hallmarks of Cancer in order to identify potential novel targets within the brain that may offer a means to treat brain cancers, including the deadliest brain cancer, glioblastoma.
Entities:
Keywords:
Glioblastoma; brain microenvironment; cancer hallmarks; tumor microenvironment
Authors: Hanna Sabelström; David A Quigley; Trenten Fenster; Daniel J Foster; Clara A M Fuchshuber; Supna Saxena; Edith Yuan; Nan Li; Francesca Paterno; Joanna J Phillips; C David James; Börje Norling; Mitchel S Berger; Anders I Persson Journal: Exp Cell Res Date: 2019-03-05 Impact factor: 3.905
Authors: Harald Krenzlin; Prajna Behera; Viola Lorenz; Carmela Passaro; Mykola Zdioruk; Michal O Nowicki; Korneel Grauwet; Hong Zhang; Magdalena Skubal; Hirotaka Ito; Rachel Zane; Michael Gutknecht; Marion B Griessl; Franz Ricklefs; Lai Ding; Sharon Peled; Arun Rooj; C David James; Charles S Cobbs; Charles H Cook; E Antonio Chiocca; Sean E Lawler Journal: J Clin Invest Date: 2019-03-11 Impact factor: 14.808
Authors: Alexander Birbrair; Anirudh Sattiraju; Dongqin Zhu; Gilberto Zulato; Izadora Batista; Van T Nguyen; Maria Laura Messi; Kiran Kumar Solingapuram Sai; Frank C Marini; Osvaldo Delbono; Akiva Mintz Journal: Stem Cells Transl Med Date: 2016-09-14 Impact factor: 6.940
Authors: J P Zepecki; K M Snyder; M M Moreno; E Fajardo; A Fiser; J Ness; A Sarkar; S A Toms; N Tapinos Journal: Oncogene Date: 2018-10-23 Impact factor: 9.867
Authors: Rut Valdor; David García-Bernal; Dolores Riquelme; Carlos M Martinez; Jose M Moraleda; Ana Maria Cuervo; Fernando Macian; Salvador Martinez Journal: Proc Natl Acad Sci U S A Date: 2019-09-23 Impact factor: 11.205
Authors: Jennifer H Hammel; Jonathan M Zatorski; Sophie R Cook; Rebecca R Pompano; Jennifer M Munson Journal: Adv Drug Deliv Rev Date: 2022-01-11 Impact factor: 15.470