| Literature DB >> 31358989 |
Joel Gelernter1,2, Ning Sun3,4, Renato Polimanti5,6, Robert Pietrzak5,6, Daniel F Levey5,6, Julien Bryois7, Qiongshi Lu4, Yiming Hu4, Boyang Li4, Krishnan Radhakrishnan3,8, Mihaela Aslan3,9, Kei-Hoi Cheung3,10, Yuli Li3,11, Nallakkandi Rajeevan3,11, Frederick Sayward3,11, Kelly Harrington12,13, Quan Chen3,4, Kelly Cho12,14, Saiju Pyarajan12,14, Patrick F Sullivan7,15, Rachel Quaden12, Yunling Shi12, Haley Hunter-Zinck12, J Michael Gaziano12,14, John Concato3,9, Hongyu Zhao3,4, Murray B Stein16,17.
Abstract
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10-10: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the African American cohort of the sample. Results in European Americans were replicated in the UK Biobank data. These results provide new insights into the biology of PTSD in a well-powered genome-wide association study.Entities:
Mesh：
Year: 2019 PMID： 31358989 PMCID： PMC6953633 DOI： 10.1038/s41593-019-0447-7
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884