OBJECTIVES: To examine whether attachment style moderates the relationship between polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) re-experiencing (PTSDREX) symptoms and the severity of and positive screen for traumatic loss-related PTSD. METHODS: Data were analysed from 631 US veterans who endorsed 'unexpected death of a loved one' as their 'worst' traumatic event. Multivariable models evaluated the association between PRS for PTSDREX, attachment style, and their interaction in predicting severity and positive screen for PTSD. A gene enrichment analysis was conducted to identify possible molecular mechanisms underlying the association between PTSDREX PRS and PTSD. RESULTS: PTSDREX PRS (β = 0.17; odds ratio [OR] = 1.85), attachment style (β= -0.33; OR = 0.14), and PTSDREX PRS × attachment style interaction (β= -0.12; OR = 0.53) were significant predictors of the severity and positive screen for PTSD. The most significant gene set detected was the gene ontology (GO) cellular component podosome set (GO:0002102, p < 3.95 × 10-5). CONCLUSIONS: Having a secure attachment style may help mitigate polygenic risk for developing traumatic loss-related PTSD in US veterans. Podosomes, which are implicated in inflammatory and neuroplasticity processes, may contribute to the genetic liability to developing loss-related PTSD. Psychological treatments targeting attachment security may help mitigate increased polygenic risk for loss-related PTSD in this population.
OBJECTIVES: To examine whether attachment style moderates the relationship between polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) re-experiencing (PTSDREX) symptoms and the severity of and positive screen for traumatic loss-related PTSD. METHODS: Data were analysed from 631 US veterans who endorsed 'unexpected death of a loved one' as their 'worst' traumatic event. Multivariable models evaluated the association between PRS for PTSDREX, attachment style, and their interaction in predicting severity and positive screen for PTSD. A gene enrichment analysis was conducted to identify possible molecular mechanisms underlying the association between PTSDREX PRS and PTSD. RESULTS: PTSDREX PRS (β = 0.17; odds ratio [OR] = 1.85), attachment style (β= -0.33; OR = 0.14), and PTSDREX PRS × attachment style interaction (β= -0.12; OR = 0.53) were significant predictors of the severity and positive screen for PTSD. The most significant gene set detected was the gene ontology (GO) cellular component podosome set (GO:0002102, p < 3.95 × 10-5). CONCLUSIONS: Having a secure attachment style may help mitigate polygenic risk for developing traumatic loss-related PTSD in US veterans. Podosomes, which are implicated in inflammatory and neuroplasticity processes, may contribute to the genetic liability to developing loss-related PTSD. Psychological treatments targeting attachment security may help mitigate increased polygenic risk for loss-related PTSD in this population.
Authors: C Benjet; E Bromet; E G Karam; R C Kessler; K A McLaughlin; A M Ruscio; V Shahly; D J Stein; M Petukhova; E Hill; J Alonso; L Atwoli; B Bunting; R Bruffaerts; J M Caldas-de-Almeida; G de Girolamo; S Florescu; O Gureje; Y Huang; J P Lepine; N Kawakami; Viviane Kovess-Masfety; M E Medina-Mora; F Navarro-Mateu; M Piazza; J Posada-Villa; K M Scott; A Shalev; T Slade; M ten Have; Y Torres; M C Viana; Z Zarkov; K C Koenen Journal: Psychol Med Date: 2015-10-29 Impact factor: 7.723
Authors: Samantha J Moshier; Daniel J Lee; Michelle J Bovin; Gabrielle Gauthier; Alexandra Zax; Raymond C Rosen; Terence M Keane; Brian P Marx Journal: J Trauma Stress Date: 2019-10
Authors: Frank R Wendt; Varun Warrier; Gita A Pathak; Karestan C Koenen; Murray B Stein; John H Krystal; Robert H Pietrzak; Joel Gelernter; Elizabeth V Goldfarb; Simon Baron-Cohen; Renato Polimanti Journal: Neurobiol Stress Date: 2022-02-21