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Literature DB >> 3135809

A modified form of microtubule-associated tau protein is the main component of paired helical filaments.

A Nieto¹, I Correas, E Montejo de Garcini, J Avila.

Abstract

Paired helical filaments, which are present in the brain of Alzheimer's disease patients have been isolated and characterized. Treatment of the filaments with reducing agents and detergents extracts several proteins from these structures. The remaining filaments are composed mainly of a protein with molecular weight of 33 kDa suggesting that this protein is the core component of these filaments. Peptide mapping using trypsin and endoproteinase Arg-C revealed that the 33 kDa protein, was a modified form of tau protein present in normal human brain.

Entities: Disease Gene Species

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Year: 1988 PMID： 3135809 DOI： 10.1016/0006-291x(88)90190-8

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

10 in total

1. Tau dephosphorylation at tau-1 site correlates with its association to cell membrane.

Authors: M Arrasate; M Pérez; J Avila
Journal: Neurochem Res Date: 2000-01 Impact factor: 3.996

2. Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.

Authors: X Bi; A P Yong; J Zhou; C E Ribak; G Lynch
Journal: Proc Natl Acad Sci U S A Date: 2001-07-03 Impact factor: 11.205

3. Role of glycosaminoglycans in determining the helicity of paired helical filaments.

Authors: M Arrasate; M Pérez; J M Valpuesta; J Avila
Journal: Am J Pathol Date: 1997-10 Impact factor: 4.307

4. Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo.

Authors: R L Neve; A Kammesheidt; C F Hohmann
Journal: Proc Natl Acad Sci U S A Date: 1992-04-15 Impact factor: 11.205

A modified form of microtubule-associated tau protein is the main component of paired helical filaments.

1. Tau dephosphorylation at tau-1 site correlates with its association to cell membrane.

2. Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.

3. Role of glycosaminoglycans in determining the helicity of paired helical filaments.

4. Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo.

5. The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide.

6. Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.

Review 7. Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

Review 8. Mechanism of Alzheimer's disease: arguments for a neurotransmitter-aluminium complex implication.

9. Characterization by atomic force microscopy of Alzheimer paired helical filaments under physiological conditions.

Review 10. The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives.