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Literature DB >> 31356877

A tale of two TrkA inhibitor trials: same target, divergent results.

D A Walsh¹, T Neogi².

Abstract

Entities: Chemical Disease Gene Species

Keywords: Clinical trial; Nerve growth factor; Osteoarthritis; Pain; TrkA inhibitor

Year: 2019 PMID： 31356877 PMCID： PMC6941477 DOI： 10.1016/j.joca.2019.07.013

Source DB: PubMed Journal: Osteoarthritis Cartilage ISSN： 1063-4584 Impact factor: 6.576

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11 in total

1. Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.

Authors: Thomas J Schnitzer; Richard Easton; Shirley Pang; Dennis J Levinson; Glenn Pixton; Lars Viktrup; Isabelle Davignon; Mark T Brown; Christine R West; Kenneth M Verburg
Journal: JAMA Date: 2019-07-02 Impact factor: 56.272

2. Antagonism of nerve growth factor-TrkA signaling and the relief of pain.

Authors: Patrick W Mantyh; Martin Koltzenburg; Lorne M Mendell; Leslie Tive; David L Shelton
Journal: Anesthesiology Date: 2011-07 Impact factor: 7.892

3. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis.

Authors: David A Walsh; Dan F McWilliams; Matthew J Turley; Madeleine R Dixon; Rebecca E Fransès; Paul I Mapp; Deborah Wilson
Journal: Rheumatology (Oxford) Date: 2010-06-26 Impact factor: 7.580

Review 4. Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of Osteoarthritis Trials.

Authors: Raveendhara R Bannuru; Timothy E McAlindon; Matthew C Sullivan; John B Wong; David M Kent; Christopher H Schmid
Journal: Ann Intern Med Date: 2015-09-01 Impact factor: 25.391

Review 5. Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?

Authors: Rachel E Miller; Joel A Block; Anne-Marie Malfait
Journal: Curr Opin Rheumatol Date: 2017-01 Impact factor: 5.006

6. Expression of NGF, Trka and p75 in human cartilage.

Authors: A Gigante; C Bevilacqua; A Pagnotta; S Manzotti; A Toesca; F Greco
Journal: Eur J Histochem Date: 2003 Impact factor: 3.188

7. Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the inflammatory response.

Authors: L Manni; T Lundeberg; S Fiorito; S Bonini; E Vigneti; L Aloe
Journal: Clin Exp Rheumatol Date: 2003 Sep-Oct Impact factor: 4.473

8. Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis.

Authors: J R Hochman; A M Davis; J Elkayam; L Gagliese; G A Hawker
Journal: Osteoarthritis Cartilage Date: 2013-09 Impact factor: 6.576

A tale of two TrkA inhibitor trials: same target, divergent results.

1. Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.

2. Antagonism of nerve growth factor-TrkA signaling and the relief of pain.

3. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis.

Review 4. Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of Osteoarthritis Trials.

Review 5. Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?

6. Expression of NGF, Trka and p75 in human cartilage.

7. Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the inflammatory response.

8. Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis.

9. Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.

10. Chronic pain after total knee arthroplasty.

1. Future projections of opioid use and cost in patients with chronic osteoarthritis pain in Spain.

2. An update on targets for treating osteoarthritis pain: NGF and TRPV1.

Review 3. New developments in osteoarthritis pharmacological therapies.

Review 4. Peripheral pain mechanisms in osteoarthritis.