Emilie T Reas1, Gail A Laughlin2, Jaclyn Bergstrom2, Donna Kritz-Silverstein2, Linda K McEvoy2,3. 1. Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. 2. Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA. 3. Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
Abstract
BACKGROUND: Although physical activity has been associated with better cognitive function and reduced dementia risk, its association with cognitive decline in normal aging remains uncertain. OBJECTIVE: To determine whether physical activity in youth and older age are associated with age-related cognitive change. METHODS: Over a period of 27 years, 2,027 community-dwelling adults (mean age 73.5; 60% women) of the Rancho Bernardo Study of Healthy Aging completed up to seven cognitive assessments, including tests of global cognitive function, executive function, verbal fluency, and episodic memory. At each visit, participants reported concurrent physical activity. At baseline (1988- 1992), participants additionally reported physical activity as a teenager and at age 30. For each age period, participants were classified as regularly active (3+ times/week) or inactive. RESULTS: Associations between concurrent physical activity and better cognitive function were stronger with advancing age on all tests, even after accounting for education, health, and lifestyle factors, as well as survival differences (ps < 0.05). Baseline physical activity did not predict rates of cognitive decline (ps > 0.40). Individuals who were physically active at age 30 and older age maintained the highest global cognitive function with advancing age (p = 0.002). CONCLUSION: Regular physical activity is associated with better cognitive function with advancing age. Physical activity in young adulthood may contribute to cognitive reserve, which together with physical activity in later years, may act to preserve cognitive function with age.
BACKGROUND: Although physical activity has been associated with better cognitive function and reduced dementia risk, its association with cognitive decline in normal aging remains uncertain. OBJECTIVE: To determine whether physical activity in youth and older age are associated with age-related cognitive change. METHODS: Over a period of 27 years, 2,027 community-dwelling adults (mean age 73.5; 60% women) of the Rancho Bernardo Study of Healthy Aging completed up to seven cognitive assessments, including tests of global cognitive function, executive function, verbal fluency, and episodic memory. At each visit, participants reported concurrent physical activity. At baseline (1988- 1992), participants additionally reported physical activity as a teenager and at age 30. For each age period, participants were classified as regularly active (3+ times/week) or inactive. RESULTS: Associations between concurrent physical activity and better cognitive function were stronger with advancing age on all tests, even after accounting for education, health, and lifestyle factors, as well as survival differences (ps < 0.05). Baseline physical activity did not predict rates of cognitive decline (ps > 0.40). Individuals who were physically active at age 30 and older age maintained the highest global cognitive function with advancing age (p = 0.002). CONCLUSION: Regular physical activity is associated with better cognitive function with advancing age. Physical activity in young adulthood may contribute to cognitive reserve, which together with physical activity in later years, may act to preserve cognitive function with age.
Authors: Emilie T Reas; Gail A Laughlin; Jaclyn Bergstrom; Donna Kritz-Silverstein; Elizabeth Barrett-Connor; Linda K McEvoy Journal: Am J Geriatr Psychiatry Date: 2017-03-16 Impact factor: 4.105
Authors: Jennifer Weuve; Jae Hee Kang; JoAnn E Manson; Monique M B Breteler; James H Ware; Francine Grodstein Journal: JAMA Date: 2004-09-22 Impact factor: 56.272
Authors: Lilian Krist; Christina Dornquast; Thomas Reinhold; Heiko Becher; Katja Icke; Ina Danquah; Stefan N Willich; Thomas Keil Journal: Int J Environ Res Public Health Date: 2020-08-31 Impact factor: 3.390
Authors: Janina Krell-Roesch; Jeremy A Syrjanen; Jelena Bezold; Sandra Trautwein; Bettina Barisch-Fritz; Klaus Boes; Alexander Woll; Erica Forzani; Walter K Kremers; Mary M Machulda; Michelle M Mielke; David S Knopman; Ronald C Petersen; Maria Vassilaki; Yonas E Geda Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.160