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Literature DB >> 31355472

53BP1-DNA repair enters a new liquid phase.

Rossana Piccinno¹, Vera Minneker¹, Vassilis Roukos¹.

Abstract

In response to DNA damage, transient repair compartments in the nucleus concentrate repair proteins and activate downstream signaling factors. In this issue of The EMBO Journal, Kilic et al show that DNA repair focal assemblies marked by accumulation of 53BP1 are phase separated liquid compartments. This liquid droplet-like behavior of 53BP1 compartments might help to coordinate local lesion recognition with global gene activation in response to DNA damage.

Entities: Gene

Mesh：

Substances：

Year: 2019 PMID： 31355472 PMCID： PMC6694213 DOI： 10.15252/embj.2019102871

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

15 in total

1. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

Authors: Avinash Patel; Hyun O Lee; Louise Jawerth; Shovamayee Maharana; Marcus Jahnel; Marco Y Hein; Stoyno Stoynov; Julia Mahamid; Shambaditya Saha; Titus M Franzmann; Andrej Pozniakovski; Ina Poser; Nicola Maghelli; Loic A Royer; Martin Weigert; Eugene W Myers; Stephan Grill; David Drechsel; Anthony A Hyman; Simon Alberti
Journal: Cell Date: 2015-08-27 Impact factor: 41.582

2. Phase separation drives heterochromatin domain formation.

Authors: Amy R Strom; Alexander V Emelyanov; Mustafa Mir; Dmitry V Fyodorov; Xavier Darzacq; Gary H Karpen
Journal: Nature Date: 2017-06-21 Impact factor: 49.962

3. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets.

Authors: Yongdae Shin; Joel Berry; Nicole Pannucci; Mikko P Haataja; Jared E Toettcher; Clifford P Brangwynne
Journal: Cell Date: 2016-12-29 Impact factor: 41.582

4. 53BP1-DNA repair enters a new liquid phase.

Authors: Rossana Piccinno; Vera Minneker; Vassilis Roukos
Journal: EMBO J Date: 2019-07-29 Impact factor: 11.598

Review 5. The emerging role of nuclear architecture in DNA repair and genome maintenance.

Authors: Tom Misteli; Evi Soutoglou
Journal: Nat Rev Mol Cell Biol Date: 2009-03-11 Impact factor: 94.444

6. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.

Authors: Adam G Larson; Daniel Elnatan; Madeline M Keenen; Michael J Trnka; Jonathan B Johnston; Alma L Burlingame; David A Agard; Sy Redding; Geeta J Narlikar
Journal: Nature Date: 2017-06-21 Impact factor: 49.962

7. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments.

Authors: Sinan Kilic; Aleksandra Lezaja; Marco Gatti; Eliana Bianco; Jone Michelena; Ralph Imhof; Matthias Altmeyer
Journal: EMBO J Date: 2019-07-01 Impact factor: 11.598

Review 8. Biomolecular condensates: organizers of cellular biochemistry.

Authors: Salman F Banani; Hyun O Lee; Anthony A Hyman; Michael K Rosen
Journal: Nat Rev Mol Cell Biol Date: 2017-02-22 Impact factor: 94.444

9. Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

Authors: Matthias Altmeyer; Kai J Neelsen; Federico Teloni; Irina Pozdnyakova; Stefania Pellegrino; Merete Grøfte; Maj-Britt Druedahl Rask; Werner Streicher; Stephanie Jungmichel; Michael Lund Nielsen; Jiri Lukas
Journal: Nat Commun Date: 2015-08-19 Impact factor: 14.919

Review 5. DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy.

Authors: Ruixue Huang; Ping-Kun Zhou
Journal: Signal Transduct Target Ther Date: 2021-07-09

5 in total

53BP1-DNA repair enters a new liquid phase.

1. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

2. Phase separation drives heterochromatin domain formation.

3. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets.

4. 53BP1-DNA repair enters a new liquid phase.

Review 5. The emerging role of nuclear architecture in DNA repair and genome maintenance.

6. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.

7. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments.

Review 8. Biomolecular condensates: organizers of cellular biochemistry.

9. Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

10. 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms.

1. 53BP1-DNA repair enters a new liquid phase.

Review 2. Multifaceted regulation and functions of 53BP1 in NHEJ‑mediated DSB repair (Review).

Review 3. Chromosome structural variation in tumorigenesis: mechanisms of formation and carcinogenesis.

4. 53BP1: guarding the genome with a novel liquid weapon.

Review 5. DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy.