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Literature DB >> 11050434

Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.

Abstract

Receptor-activated phosphoinositide (PI) 3-kinases produce PtdIns(3, 4,5)P(3) and its metabolite PtdIns(3,4)P(2) that function as second messengers in membrane recruitment and activation of target proteins. The cytohesin and centaurin protein families are potential targets for PtdIns(3,4,5)P(3) that also regulate and interact with Arf GTPases. Consequently, these families are poised to transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. Proposed downstream events in PI 3-kinase-regulated Arf cascades include modulation of vesicular trafficking and the actin cytoskeleton.

Entities: Chemical Gene

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Year: 2000 PMID： 11050434 DOI： 10.1016/s0968-0004(00)01644-3

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

44 in total

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6. Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle.

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Journal: Diabetes Date: 2017-04-12 Impact factor: 9.461

Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.

1. The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).

2. Suppression subtractive hybridization and microarray identification of estrogen-regulated hypothalamic genes.

3. What we have learnt about PIKE from the knockout mice.

4. Arf6 plays an early role in platelet activation by collagen and convulxin.

5. Distinguishing modes of eukaryotic gradient sensing.

6. Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle.

7. GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid.

8. Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice.

9. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

10. Requirement for Arf6 in breast cancer invasive activities.