Ángela Bernabéu-Sanz1, José Vicente Mollá-Torró2, Susana López-Celada3, Pedro Moreno López2, Eduardo Fernández-Jover4,5. 1. Magnetic Resonance Department, Inscanner SL, C/San Pedro Poveda, 10, 03010, Alicante, Spain. angela.bernabeu@gmail.com. 2. Department of Neurosurgery, Hospital General Universitario de Alicante, Alicante, Spain. 3. Magnetic Resonance Department, Inscanner SL, C/San Pedro Poveda, 10, 03010, Alicante, Spain. 4. Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, Spain. 5. Centro de Investigación Biomédica en Red (CIBER BBN), Madrid, Spain.
Abstract
OBJECTIVES: To investigate the effect of cervical spondylosis (CS) in the brain with a combination of advanced neuroimaging techniques. METHODS: Twenty-seven patients with CS and 24 age- and gender-matched healthy controls were studied. Disease severity was quantified using the Modified Japanese Orthopaedic Association Scoring System (mJOHA). Magnetic resonance (MR) imaging of the brain and spinal cord, functional MR imaging (fMRI) with a bilateral rest/finger-tapping paradigm, brain diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and MR spectroscopy of the sensorimotor cortex were performed. RESULTS: A total of 92.3% of patients had more than one herniated disc. In the MRI, 33.33% presented signs of myelopathy. The mJOHA score was 13.03 ± 2.83. Compared with controls, DTI results showed significant lower FA values in Corpus callosum, both corticospinal tracts and middle cerebellar peduncles (p < 0.05 corrected). Only in CS patients fMRI results showed activation in both globus pallidi, caudate nucleus, and left thalamus (p < 0.001). Subject-specific activation of the BOLD signal showed in CS patients lower activation in the sensorimotor cortex and increased activation in both cerebellum hemispheres (p < 0.05 corrected). VBM showed bilateral clusters of gray matter loss in the sensorimotor cortex and pulvinar nucleus (p < 0.05 corrected) of CS patients. NAA/Cr was reduced in the sensorimotor cortex of CS patients (p < 0.05). Linear discriminant and support vector machine analyses were able to classify > 97% of CS patients with parameters obtained from the fMRI, DTI, and MRS results. CONCLUSION: CS may lead to distal brain damage affecting the white and gray matter of the sensorimotor cortex causing brain atrophy and functional adaptive changes. KEY POINTS: • This study suggests that patients with cervical spondylosis may present anatomical and functional adaptive changes in the brain. • Cervical spondylosis may lead to white matter damage, gray matter volume loss, and functional adaptive changes in the sensorimotor cortex. • The results reported in this work may be of value to better understand the effect of prolonged cervical spine compression in the brain.
OBJECTIVES: To investigate the effect of cervical spondylosis (CS) in the brain with a combination of advanced neuroimaging techniques. METHODS: Twenty-seven patients with CS and 24 age- and gender-matched healthy controls were studied. Disease severity was quantified using the Modified Japanese Orthopaedic Association Scoring System (mJOHA). Magnetic resonance (MR) imaging of the brain and spinal cord, functional MR imaging (fMRI) with a bilateral rest/finger-tapping paradigm, brain diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and MR spectroscopy of the sensorimotor cortex were performed. RESULTS: A total of 92.3% of patients had more than one herniated disc. In the MRI, 33.33% presented signs of myelopathy. The mJOHA score was 13.03 ± 2.83. Compared with controls, DTI results showed significant lower FA values in Corpus callosum, both corticospinal tracts and middle cerebellar peduncles (p < 0.05 corrected). Only in CS patients fMRI results showed activation in both globus pallidi, caudate nucleus, and left thalamus (p < 0.001). Subject-specific activation of the BOLD signal showed in CS patients lower activation in the sensorimotor cortex and increased activation in both cerebellum hemispheres (p < 0.05 corrected). VBM showed bilateral clusters of gray matter loss in the sensorimotor cortex and pulvinar nucleus (p < 0.05 corrected) of CS patients. NAA/Cr was reduced in the sensorimotor cortex of CS patients (p < 0.05). Linear discriminant and support vector machine analyses were able to classify > 97% of CS patients with parameters obtained from the fMRI, DTI, and MRS results. CONCLUSION: CS may lead to distal brain damage affecting the white and gray matter of the sensorimotor cortex causing brain atrophy and functional adaptive changes. KEY POINTS: • This study suggests that patients with cervical spondylosis may present anatomical and functional adaptive changes in the brain. • Cervical spondylosis may lead to white matter damage, gray matter volume loss, and functional adaptive changes in the sensorimotor cortex. • The results reported in this work may be of value to better understand the effect of prolonged cervical spine compression in the brain.
Authors: M Xiangshui; C Xiangjun; Z Xiaoming; Z Qingshi; C Yi; Q Chuanqiang; M Xiangxing; L Chuanfu; H Jinwen Journal: Clin Radiol Date: 2010-04-18 Impact factor: 2.350
Authors: Jan Valošek; Petr Bednařík; Miloš Keřkovský; Petr Hluštík; Josef Bednařík; Alena Svatkova Journal: J Clin Med Date: 2022-04-20 Impact factor: 4.964
Authors: Jan Valošek; René Labounek; Tomáš Horák; Magda Horáková; Petr Bednařík; Miloš Keřkovský; Jan Kočica; Tomáš Rohan; Christophe Lenglet; Julien Cohen-Adad; Petr Hluštík; Eva Vlčková; Zdeněk Kadaňka; Josef Bednařík; Alena Svatkova Journal: Eur J Neurol Date: 2021-08-04 Impact factor: 6.288