Literature DB >> 313431

Reversal of nzb/nzw disease with total lymphoid irradiation.

B L Kotzin, S Strober.   

Abstract

NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6-mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and decrease in anti-DNA antibodies as compared to control animals. Few side effects were observed in the treated group. TLI also prolonged survival in animals with advanced renal disease. These findings suggest that TLI may have application to the treatment of human SLE.

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Year:  1979        PMID： 313431      PMCID： PMC2185621          DOI： 10.1084/jem.150.2.371

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  26 in total

1.  Use of total lymphoid irradiation in tissue transplantation in mice.

Authors:  S Slavin; S Strober; Z Fuks; H S Kaplan
Journal:  Transplant Proc       Date:  1977-03       Impact factor: 1.066

2.  Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Authors:  Z Fuks; S Strober; A M Bobrove; T Sasazuki; A McMichael; H S Kaplan
Journal:  J Clin Invest       Date:  1976-10       Impact factor: 14.808

3.  Hematologic neoplasia in patients treated for Hodgkin's disease.

Authors:  C N Coleman; C J Williams; A Flint; E J Glatstein; S A Rosenberg; H S Kaplan
Journal:  N Engl J Med       Date:  1977-12-08       Impact factor: 91.245

4.  Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation.

Authors:  S Slavin; M Gottlieb; S Strober; C Bieber; R Hoppe; H S Kaplan; F C Grumet
Journal:  Transplantation       Date:  1979-02       Impact factor: 4.939

5.  Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in NZP-NZW mice.

Authors:  B H Hahn; M K Bagby; T R Hamilton; C K Osterland
Journal:  Arthritis Rheum       Date:  1973 Mar-Apr

6.  Demonstration of activation of B lymphocytes in New Zealand black mice at birth by an immunoradiometric assay for murine IgM.

Authors:  H M Moutsopoulos; M Boehm-Truitt; S S Kassan; T M Chused
Journal:  J Immunol       Date:  1977-11       Impact factor: 5.422

7.  Induction and mechanism of tolerance to bovine serum albumin in mice given total lymphoid irradiation (TLI).

Authors:  I Zan-Bar; S Slavin; S Strober
Journal:  J Immunol       Date:  1978-10       Impact factor: 5.422

8.  Ribavirin: efficacy in the treatment of murine autoimmune disease.

Authors:  L W Klassen; D R Budman; G W Williams; A D Steinberg; N L Gerber
Journal:  Science       Date:  1977-02-25       Impact factor: 47.728

9.  Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.

Authors:  S Slavin; S Strober; Z Fuks; H S Kaplan
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307

10.  Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.

Authors:  S Slavin; B Reitz; C P Bieber; H S Kaplan; S Strober
Journal:  J Exp Med       Date:  1978-03-01       Impact factor: 14.307
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  11 in total

1.  Genetic analysis of the imperfect association of H-2 haplotype with lupus-like autoimmune disease.

Authors:  S K Babcock; V B Appel; M Schiff; E Palmer; B L Kotzin
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: II. Reduction of glomerulonephritis.

Authors:  H C Gunn; B Ryffel
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

3.  New approaches to treating systemic lupus erythematosus.

Authors:  D Wofsy
Journal:  West J Med       Date:  1987-08

4.  Marrow transplantation from tolerant donors to treat and prevent autoimmune diseases in BXSB mice.

Authors:  K Himeno; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

5.  In vitro X-ray irradiation of human peripheral blood T lymphocytes enhances suppressor function.

Authors:  H Ogawa; T Tsunematsu
Journal:  Clin Exp Immunol       Date:  1983-08       Impact factor: 4.330

6.  Immunomodulation of autoimmunity in MRL/lpr mice with syngeneic bone marrow transplantation (SBMT).

Authors:  D M Karussis; U Vourka-Karussis; D Lehmann; O Abramsky; A Ben-Nun; S Slavin
Journal:  Clin Exp Immunol       Date:  1995-04       Impact factor: 4.330

7.  Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. Evidence for a T cell defect.

Authors:  E G Engleman; C J Benike; R T Hoppe; H S Kaplan; F R Berberich
Journal:  J Clin Invest       Date:  1980-07       Impact factor: 14.808

8.  Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: I. Reduction of autoantibodies.

Authors:  H C Gunn
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

9.  Prolongation of life in female NZB/NZW (F1) hybrid mice by cyclosporin A.

Authors:  M G Jones; G Harris
Journal:  Clin Exp Immunol       Date:  1985-01       Impact factor: 4.330

10.  The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.

Authors:  B L Kotzin; E Palmer
Journal:  J Exp Med       Date:  1987-05-01       Impact factor: 14.307
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