Aim: This study evaluates scaffold degradation and neotissue formation as a function of sealant polymer composition in tissue-engineered vascular grafts (TEVGs). Materials & methods: Scaffolds fabricated from polyglycolic acid core and sealant composed of polycaprolactone (PCL), poly-L-lactic-acid (PLLA) or 50:50 copolymer poly(ε-caprolactone-co-L-lactide) (PCLA) were analyzed in vitro using accelerated degradation and scanning electron microscopy, and in vivo following implantation in a murine inferior vena cava interposition model. Results: In vitro and in vivo characterization revealed statistically greater degradation of PCLA compared with both PCL and PLLA scaffolds, with similar neotissue formation across all groups. The wall thickness of PLLA TEVGs was statistically greater than PCL TEVGs at 2 weeks postimplant. Conclusion: Results of this study can be used to inform the rational design of future TEVGs.
Aim: This study evaluates scaffold degradation and neotissue formation as a function of sealant polymer composition in tissue-engineered vascular grafts (TEVGs). Materials & methods: Scaffolds fabricated from polyglycolic acid core and sealant composed of polycaprolactone (PCL), poly-L-lactic-acid (PLLA) or 50:50 copolymer poly(ε-caprolactone-co-L-lactide) (PCLA) were analyzed in vitro using accelerated degradation and scanning electron microscopy, and in vivo following implantation in a murine inferior vena cava interposition model. Results: In vitro and in vivo characterization revealed statistically greater degradation of PCLA compared with both PCL and PLLA scaffolds, with similar neotissue formation across all groups. The wall thickness of PLLA TEVGs was statistically greater than PCL TEVGs at 2 weeks postimplant. Conclusion: Results of this study can be used to inform the rational design of future TEVGs.
Authors: Narutoshi Hibino; Tai Yi; Daniel R Duncan; Animesh Rathore; Ethan Dean; Yuji Naito; Alan Dardik; Themis Kyriakides; Joseph Madri; Jordan S Pober; Toshiharu Shinoka; Christopher K Breuer Journal: FASEB J Date: 2011-08-24 Impact factor: 5.191
Authors: Jason D Roh; Gregory N Nelson; Matthew P Brennan; Tamar L Mirensky; Tai Yi; Tyrone F Hazlett; George Tellides; Albert J Sinusas; Jordan S Pober; W M Saltzman; Themis R Kyriakides; Christopher K Breuer Journal: Biomaterials Date: 2007-12-27 Impact factor: 12.479
Authors: Ramak Khosravi; Cameron A Best; Robert A Allen; Chelsea E T Stowell; Ekene Onwuka; Jennifer J Zhuang; Yong-Ung Lee; Tai Yi; Matthew R Bersi; Toshiharu Shinoka; Jay D Humphrey; Yadong Wang; Christopher K Breuer Journal: Ann Biomed Eng Date: 2016-01-21 Impact factor: 3.934
Authors: Brooks V Udelsman; Ramak Khosravi; Kristin S Miller; Ethan W Dean; Matthew R Bersi; Kevin Rocco; Tai Yi; Jay D Humphrey; Christopher K Breuer Journal: J Biomech Date: 2014-03-15 Impact factor: 2.712
Authors: Kevin M Blum; Jacob C Zbinden; Abhay B Ramachandra; Stephanie E Lindsey; Jason M Szafron; Aaron J Trask; Jay D Humphrey; Alison L Marsden; Toshiharu Shinoka; Christopher K Breuer; James W Reinhardt; Megan Heitkemper; Cameron A Best; Gabriel J M Mirhaidari; Yu-Chun Chang; Anudari Ulziibayar; John Kelly; Kejal V Shah; Joseph D Drews; Jason Zakko; Shinka Miyamoto; Yuichi Matsuzaki; Ryuma Iwaki; Hira Ahmad; Robbie Daulton; Drew Musgrave; Matthew G Wiet; Eric Heuer; Emily Lawson; Erica Schwarz; Michael R McDermott; Rajesh Krishnamurthy; Ramkumar Krishnamurthy; Kan Hor; Aimee K Armstrong; Brian A Boe; Darren P Berman Journal: Commun Med (Lond) Date: 2022-01-10
Authors: Kevin M Blum; Lauren C Roby; Jacob C Zbinden; Yu-Chun Chang; Gabriel J M Mirhaidari; James W Reinhardt; Tai Yi; Jenny C Barker; Christopher K Breuer Journal: Sci Rep Date: 2021-04-13 Impact factor: 4.379
Authors: Erica L Schwarz; John M Kelly; Kevin M Blum; Kan N Hor; Andrew R Yates; Jacob C Zbinden; Aekaansh Verma; Stephanie E Lindsey; Abhay B Ramachandra; Jason M Szafron; Jay D Humphrey; Toshiharu Shin'oka; Alison L Marsden; Christopher K Breuer Journal: NPJ Regen Med Date: 2021-07-22