Systematic review protocol for facilitators and barriers to integrating health services for traumatic brain injury and mental health or addictions.

INTRODUCTION: In the most populous province of Canada, one in five adults and one in six students report a lifetime history of traumatic brain injury (TBI). These individuals were also more likely to report elevated psychological distress and use illicit substances compared with those without TBI. The need for integrated health services has been recognised globally, yet efforts to develop more comprehensive and effective care for TBI and mental health and/or addictions (MHA) continue to be challenged by the siloing of the two systems. This protocol is for a systematic review that describes the current types of integrated care for TBI and MHA and identifies the barriers and facilitators to integrating healthcare for these populations. METHODS AND ANALYSIS: This review will systematically search MEDLINE, EMBASE, PsycINFO, CINAHL, Cochrane Central Register of Controlled Trials, Sociological Abstracts, and Dissertations & Theses Global. References of eligible articles will also be searched for additional relevant studies. The search strategy will include the use of text words and subject headings relevant to the concepts 'TBI,' 'substance abuse, gambling, or mental health,' 'integrated healthcare,' 'barriers and facilitators,' and 'healthcare access.' Two reviewers will independently screen all articles based on predetermined inclusion and exclusion criteria and perform quality assessment on eligible studies. A narrative synthesis will be conducted using the data abstracted by the two reviewers. ETHICS AND DISSEMINATION: Findings from the systematic review will be published in peer-reviewed journals, presented at scientific meetings, and summarised for key stakeholders in the field of TBI and/or MHA. This protocol will form a systematic review that holds the potential to impact policy and planning in the development of integrated person-centred care for TBI and MHA and addresses a recognised gap in TBI care. TRIAL REGISTRATION NUMBER: CRD42018108343. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

The exclusion of non-English language studies, thereby omitting evidence on integrating traumatic brain injury (TBI) and mental health and/or addictions (MHA) in jurisdictions where findings are not published in English, limits the comprehensiveness of the systematic review.

Recognising not all studies will explicitly describe a policy, intervention, service delivery, or programme as integrating TBI and MHA care, the primary search strategy (TBI, MHA, and integrated care) will be supplemented with an additional search that aims to capture articles describing barriers and facilitators to healthcare for TBI and MHA (TBI, MHA, barriers and facilitators, and healthcare access) to maximise the return of relevant articles.

At both screening stages, a random selection of articles will first be selected for independent review to enable the reviewers to meet and to establish and document a common extraction and interpretation technique; the reviewers will also meet regularly to review the articles that are included/excluded to ensure consistency in the interpretation of the predetermined inclusion criteria.

Introduction

Traumatic brain injury (TBI) has been defined as ‘an alteration in brain function, or other evidence of brain pathology, caused by an external force.’1 It is more common than breast cancer, HIV/AIDS, spinal cord injury, and multiple sclerosis combined,2–5 and the indirect economic costs due to a TBI is projected to be $8.2 billion by 2031 in Canada alone. This exceeds costs of other common neurological conditions, including epilepsy, multiple sclerosis, and dementias including Alzheimer’s disease.6 In Ontario, Canada, home to 39% of Canadians,7 one in six adults8 and one in five students9 report a lifetime history of TBI. These individuals were also at least 52% more likely to have elevated psychological distress,10 100% more likely to use cannabis,11 93% more likely to experience suicidal ideation,10 and 239% more likely to have attempted suicide10 compared with those without a history of TBI. Literature exploring the relationship between TBI and mental health and/or addictions (MHA) has found that MHA is prevalent after TBI across the lifespan, particularly diagnoses of schizophrenia, depression, anxiety, substance use disorder, post-traumatic stress disorder, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD).12–22 It is noteworthy that among individuals with an MHA, a history of TBI is also common.12 23

Despite these alarming statistics and the plethora of research establishing a relationship between TBI and MHA, a systems analysis of community and health services for TBI in Ontario identified a lack of appropriate services and community support for individuals with a TBI and MHA.24 Efforts to develop more effective and early intervention and care continue to be challenged by the current siloing of the TBI and MHA systems. This need for integrated healthcare has been recognised globally25 26 and across many health conditions and settings.27–32 Most recently, the World Health Assembly adopted the ‘Framework on Integrated People-Centred Health Services’33 with the vision that ‘all people have equal access to quality health services that are co-produced in a way that meets their life course needs and respects social preferences, are coordinated across the continuum of care, and are comprehensive, safe, effective, timely, efficient, and acceptable; and all carers are motivated, skilled and operate in a supportive environment.’33 Such integrated care is attractive, as it holds the potential to enable health systems to provide care that addresses the priorities and needs of persons with lived experience, improving their experiences in transitions across their continuum of care, to positively impact patient outcome and quality of life.

Building on this vision, this protocol is for a systematic review that (1) describes the current types of integrated care for TBI and MHA, including access to MHA services for the TBI population and access to TBI services for the MHA population, and (2) identifies the barriers and facilitators to integrating health services for individuals with TBI and MHA. It is recognised that there are numerous concepts and definitions of integration that are currently applied in the literature,33 34 as many factors impact the delivery of health services in any given setting,34 35 making it difficult to identify one definition of health service integration. As such, this protocol will form a systematic review that aims to identify all forms of integration of care (e.g., vertical, horizontal, clinical, and functional integration) to inform policy and programmes to develop integrated care for TBI and MHA.

Methods and analysis

Search strategy

The following databases will be searched for relevant articles:

MEDLINE In-Process and Other Non-Indexed Citations and MEDLINE.

EMBASE.

PsycINFO.

CINAHL.

Cochrane Central Register of Controlled Trials.

Sociological Abstracts.

Dissertations & Theses Global.

The search strategy for this protocol is available through the online supplementary file. This search strategy will include the use of text words and subject headings (e.g., Medical Subject Headings (MeSH), Emtree) related to the following concepts:

TBI.

Substance abuse, gambling, or mental health.

Integrated healthcare.

Barrier and facilitator.

Healthcare access.

The primary search strategy (concepts A+B+C) will identify papers that discuss integrated healthcare in a population with TBI and MHA. To complement this primary search strategy, an additional search (concepts A+B+D+E) will be included, based on the search strategies of other published reviews27 31 32 36–38 and the ‘Framework on Integrated People-Centred Health Services,’ adopted by the WHO in 2016.33 These two searches will be combined with an ‘OR’ statement to complete the strategy for each of the databases searched, with the exception of the database Sociological Abstracts, where the strategy will be reduced (concepts A+B) due to paucity of results.

Searches will be limited to English language publications and exclude animal studies when possible. Additional limits and search fields will be applied, when applicable, to exclude conference abstracts, magazines, books, and encyclopaedias. Records returned from this search strategy will be managed in EndNote.

Study selection

For all databases, a first screen will be conducted by two reviewers who will independently assess all titles and abstracts for eligibility based on pre-inclusion criteria:

Describe or evaluate a (a) policy, (b) programme, or (c) intervention/treatment at the health service delivery level for individuals with TBI and/or MHA identified in the literature to be prevalent among the TBI population (addictions/substance use, problem gambling, mood and personality disorders, schizophrenia and psychosis, anxiety and depression, trauma and stress disorder, OCD, ADHD, conduct disorder)12–23;

Screen or diagnosis for a TBI in a health service for MHA;

Screen or diagnosis for a MHA in a health service for TBI;

Quantitative, qualitative, or mixed method studies, or review papers that report primary research findings related to TBI and/or MHA care;

Full-text available.

Articles that meet all of the above criteria will be included for the second screen, which will be a full-text screen. However, articles that are narrative, commentaries, or describe a theory or framework, and articles that look at the broader brain injury population (eg, acquired brain injury, patients with trauma) without specific mention of TBI will be excluded.

Recognising that reviewers may interpret the above pre-determined inclusion criteria differently, a random selection of abstracts and titles will first be selected for independent review so the reviewers can meet to establish and document a common extraction and interpretation technique. The reviewers will then meet regularly to review the abstracts that are included/excluded to ensure consistency in the interpretation of the predetermined inclusion criteria.

Two reviewers will independently assess the full-text articles for fulfilment of the following predetermined inclusion criteria:

Describe or evaluate a (a) policy, (b) programme, or (c) intervention/treatment at the health service delivery level for individuals with TBI and MHA of interest;

Screen or diagnosis for a TBI in a health service for MHA;

Screen or diagnosis for an MHA in a health service for TBI;

Describe or evaluate an actual, applied experience of integration.

The reference lists of included full-text articles will also be hand-searched for additional relevant articles. The study selection process and the reasons for exclusions at the full-text level will be presented using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses study flow diagram. Similar to the title and abstract screen, the reviewers will first review a random selection of articles to establish a common extraction and interpretation technique and will meet regularly to ensure consistency in the interpretation of the inclusion criteria.

Data extraction

The following data will be abstracted independently by two reviewers, with the goal of extracting standardised information that describes the context of the integration activity and associated barriers and facilitators:

Author and publication year.

Country of study.

Funding source (potential conflict of interest from funding? Y/N).

Research objective(s).

Study design.

Overall and sex-specific/gender-specific participant characteristics and sample size—for example, sociodemographics (age, race/ethnicity, and other measures of socioeconomic status), TBI (Y/N, severity, cause of injury, time since injury), MHA (Y/N—specify condition(s), time since diagnosis), comorbidities.

Description of integration activity.

Results of integration activity (stratified by sex/gender, if available).

Barriers (stratified by sex/gender, if available).

Facilitators (stratified by sex/gender, if available).

Additional comments/notes from reviewers.

Similar to the study selection process, the reviewers will first conduct data extraction on select articles to establish a common interpretation and extraction technique and will meet regularly to ensure consistency in the data extracted.

Quality assessment

Controlled intervention; observational cohort; cross-sectional, case-control, before-after (pre-post) with no control group; and case series studies, as well as systematic reviews and meta-analyses, will be assessed using quality assessment tools created specifically for each study design by the methodologists from the National Institutes of Health and Research Triangle Institute International.39 Qualitative studies will be assessed using the Critical Appraisal Skills Programme (CASP) checklist.40 Two reviewers will independently assess each article that passes the full-text screen. In the case of rating discrepancies, reviewers will either come to a consensus or a third, independent reviewer will evaluate the study and resolve any disagreements.

Data synthesis

A narrative synthesis will be conducted using tools and techniques informed by the Guidance on the Conduct of Narrative Synthesis in Systematic Reviews.41 The extracted data elements described above and results from the quality assessment will be ‘tabulated.’ Where data are available, the extracted data elements will be tabulated by sex (if the original study examined sex as it relates to the biological attributes associated with ‘physical and physiological features including chromosomes, gene expression, hormone levels and functions, and reproductive/sexual anatomy’)42 and gender (if the original study examined and intended to assess ‘the constructed roles, behaviours, expressions, and identifies of girls, women, boys, men, and gender diverse people’).42 These findings will be ‘grouped and clustered’ into the five recommended strategies of the ‘Framework on Integrated Person-Centred Care’33 and, where applicable, type/context of integrated care/activity. Finally, a ‘textual description’ will summarise each included study, focusing on the type of integrated care/activity as it relates to the recommended strategies of the Framework, and associated sex-specific/gender-specific barriers and facilitators.

Patient and public involvement

Patients and the public were not involved in the creation of this systematic review protocol.

However, this work is part of a larger programme of research entitled ‘Integrating Brain Injury, Mental Health, and Addiction’, funded by the Ontario Ministry of Health and Long-Term Care, that received input from individuals with lived experience and representatives of organisations that serve the TBI, MHA, housing, criminal justice, and violence against women sectors.

Ethics and dissemination

Ethics review will not be required because only publicly available, published data will be analysed. Findings from the systematic review will be published in a peer-reviewed journal, presented at scientific meetings, and summarised for stakeholders of the ‘Integrating Brain Injury, Mental Health, and Addictions Research Programme,’ funded by the Ontario Ministry of Health and Long-Term Care.43

Strengths and limitations

It is recognised that a major limitation of this systematic review is the exclusion of non-English language studies. Evidence on integrating TBI and MHA in jurisdictions where English is not a primary language may be missed, limiting the comprehensiveness of this systematic review. Additionally, unpublished results will not be identified in our systematic review, further limiting its comprehensiveness. Recognising the value of integrated activities whose results are not published in peer-reviewed journals, this protocol includes a process to systematically identify reports and theses to maximise the capture of findings related to integrated care for the TBI and MHA populations.

There are numerous strengths of this review, including those that aim to maximise the retrieval and inclusion of relevant data. The primary search strategy for this review will be supplemented with a secondary search, aimed to capture articles that describe integrations of healthcare but do not describe their study as such. This was added, recognising that some non-specific treatments and interventions, such as screening for a TBI among individuals with MHA, may not be described as a form of integration and would be missed in the primary search. This additional search will ensure that non-specific treatments and integrated care are captured in this review. Similarly, the title and abstract screen will be purposely broad to include articles that describe policy, programmes, or interventions/treatments for individuals with TBI and/or MHA, recognising that many abstracts may focus on describing data primarily for only the TBI or MHA populations. Including these articles for the full-text screen will reduce the risk of missing relevant articles that describe their study predominantly from the perspective of TBI or MHA. Finally, theses will also be searched to capture early work, such as pilots, of integrated care for TBI and MHA that may not be published in peer-reviewed journals.

To the best of our knowledge, this is the first protocol for a systematic review that describes the types of integrated care for TBI and MHA currently implemented and identifies the barriers and facilitators to integrating care for this population. Informed by the internationally adopted Framework on Integrated Person-Centred Health Services,33 findings hold the potential to impact policy and planning for integrated care for TBI and MHA and address a recognised gap in TBI care.