Literature DB >> 31331245

The clinical application of gene editing: ethical and social issues.

Kelly E Ormond1, Yvonne Bombard2,3, Vence L Bonham4, Lily Hoffman-Andrews5, Heidi Howard6,7, Rosario Isasi8, Kiran Musunuru9, Kirsten A Riggan10, Marsha Michie11, Megan Allyse12.   

Abstract

Gene-editing techniques have progressed rapidly in the past 5 years. There are already ongoing human somatic gene-editing clinical trials for multiple diseases. And there has been one purported scenario of human germline gene editing in late 2018. In this paper, we will review the current state of the technology, discuss the ethical and social issues that surround the various forms of gene editing, as well as review emerging stakeholder data from professionals, the 'general public' and individuals and families dealing with genetic diseases potentially treatable by gene editing.

Entities:  

Keywords:  CRISPR; clinical trials; ethics; gene editing; genome editing; germline gene editing; professional attitudes; public attitudes; somatic gene editing; stakeholder research

Mesh:

Year:  2019        PMID: 31331245     DOI: 10.2217/pme-2018-0155

Source DB:  PubMed          Journal:  Per Med        ISSN: 1741-0541            Impact factor:   2.512


  5 in total

1.  Human genome editing and the identity politics of genetic disability.

Authors:  Felicity Boardman
Journal:  J Community Genet       Date:  2019-09-06

2.  The Meaning of Informed Consent: Genome Editing Clinical Trials for Sickle Cell Disease.

Authors:  Stacy Desine; Brittany M Hollister; Khadijah E Abdallah; Anitra Persaud; Sara Chandros Hull; Vence L Bonham
Journal:  AJOB Empir Bioeth       Date:  2020-10-12

3.  Germline genome modification through novel political, ethical, and social lenses.

Authors:  Vicki Xafis; G Owen Schaefer; Markus K Labude; Yujia Zhu; Soren Holm; Roger Sik-Yin Foo; Poh San Lai; Ruth Chadwick
Journal:  PLoS Genet       Date:  2021-09-09       Impact factor: 5.917

4.  Better governance starts with better words: why responsible human tissue research demands a change of language.

Authors:  Michael A Lensink; Karin R Jongsma; Sarah N Boers; Annelien L Bredenoord
Journal:  BMC Med Ethics       Date:  2022-09-01       Impact factor: 2.834

Review 5.  Genome editing via non-viral delivery platforms: current progress in personalized cancer therapy.

Authors:  Tianxia Lan; Haiying Que; Min Luo; Xia Zhao; Xiawei Wei
Journal:  Mol Cancer       Date:  2022-03-11       Impact factor: 27.401

  5 in total

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