Literature DB >> 31326902

Cardiac arrest in a young healthy male patient secondary to kratom ingestion: is this 'legal high' substance more dangerous than initially thought ?

Hafez Mohammad Ammar Abdullah1, Iqra Haq1, Randall Lamfers1.   

Abstract

Kratom is a psychoactive herb that has stimulant properties at low doses and has opioid-like properties at higher doses. It has been used for centuries in southeast Asia as a stimulant but has gained increasing popularity as a substitute for opioids in western countries as it is easily available. As most cases of kratom use involve other drugs too, the Food and Drug Administration (FDA) has stopped short of restricting kratom due to difficulty in assessing the adverse effects of kratom alone. We present the case of a young healthy 35-year-old man who suffered a cardiac arrest due to kratom use with no other coingestants. He was subsequently intubated and found to have systolic dysfunction and small brain infarcts. Fortunately, he made a successful recovery and was discharged after a stay at thebehavioural health centre. Our case highlights the potential adverse effects of kratom and the need to regulate its use. © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  drugs misuse (including addiction); drugs: psychiatry; global health; public health

Mesh:

Substances:

Year:  2019        PMID: 31326902      PMCID: PMC6663180          DOI: 10.1136/bcr-2019-229778

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  37 in total

Review 1.  A Case Report of Kratom Addiction and Withdrawal.

Authors:  David Galbis-Reig
Journal:  WMJ       Date:  2016-02

2.  The Children's Hospitals Neonatal Database: an overview of patient complexity, outcomes and variation in care.

Authors:  K Murthy; F D Dykes; M A Padula; E K Pallotto; K M Reber; D J Durand; B L Short; J M Asselin; I Zaniletti; J R Evans
Journal:  J Perinatol       Date:  2014-03-06       Impact factor: 2.521

3.  Severity of Kratom (Mitragyna speciosa Korth.) Psychological Withdrawal Symptoms.

Authors:  Darshan Singh; Suresh Narayanan; Christian P Müller; Marc T Swogger; Azlan Abdul Rahim; Mohammad Farris Iman Leong Bin Abdullah; Balasingam K Vicknasingam
Journal:  J Psychoactive Drugs       Date:  2018-08-28

4.  Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.

Authors:  András Váradi; Gina F Marrone; Travis C Palmer; Ankita Narayan; Márton R Szabó; Valerie Le Rouzic; Steven G Grinnell; Joan J Subrath; Evelyn Warner; Sanjay Kalra; Amanda Hunkele; Jeremy Pagirsky; Shainnel O Eans; Jessica M Medina; Jin Xu; Ying-Xian Pan; Attila Borics; Gavril W Pasternak; Jay P McLaughlin; Susruta Majumdar
Journal:  J Med Chem       Date:  2016-09-02       Impact factor: 7.446

5.  Intrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa).

Authors:  Friedrich G Kapp; Hans H Maurer; Volker Auwärter; Martin Winkelmann; Maren Hermanns-Clausen
Journal:  J Med Toxicol       Date:  2011-09

Review 6.  Pharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects.

Authors:  Walter C Prozialeck; Jateen K Jivan; Shridhar V Andurkar
Journal:  J Am Osteopath Assoc       Date:  2012-12

7.  Kratom abuse in Ramathibodi Poison Center, Thailand: a five-year experience.

Authors:  Satariya Trakulsrichai; Achara Tongpo; Charuwan Sriapha; Sunun Wongvisawakorn; Panee Rittilert; Sming Kaojarern; Winai Wananukul
Journal:  J Psychoactive Drugs       Date:  2013 Nov-Dec

8.  Use of Kratom, an Opioid-like Traditional Herb, in Pregnancy.

Authors:  Marcela C Smid; Jasmin E Charles; Adam J Gordon; Tricia E Wright
Journal:  Obstet Gynecol       Date:  2018-10       Impact factor: 7.661

9.  Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes.

Authors:  Jun Lu; Heming Wei; Jianjun Wu; Mohd Fadzly Amar Jamil; Mei Lan Tan; Mohd Ilham Adenan; Philip Wong; Winston Shim
Journal:  PLoS One       Date:  2014-12-23       Impact factor: 3.240

Review 10.  The abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research.

Authors:  Jack E Henningfield; Reginald V Fant; Daniel W Wang
Journal:  Psychopharmacology (Berl)       Date:  2017-12-23       Impact factor: 4.530

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  4 in total

Review 1.  Health Effects Associated With Kratom (Mitragyna speciosa) and Polysubstance Use: A Narrative Review.

Authors:  Catherine W Striley; Carolin C Hoeflich; Andrew T Viegas; Lindsey A Berkowitz; Emily G Matthews; Leyla P Akin; Chidinma Iheanyi-Okeahialam; Urmeen Mansoor; Christopher R McCurdy
Journal:  Subst Abuse       Date:  2022-05-20

Review 2.  Kratom-Pharmacology, Clinical Implications, and Outlook: A Comprehensive Review.

Authors:  Steven C Eastlack; Elyse M Cornett; Alan D Kaye
Journal:  Pain Ther       Date:  2020-01-28

3.  Case Report: Treatment of Kratom Use Disorder With a Classical Tricyclic Antidepressant.

Authors:  Alessandro E Vento; Simone de Persis; Sergio De Filippis; Fabrizio Schifano; Flavia Napoletano; John M Corkery; Georgios D Kotzalidis
Journal:  Front Psychiatry       Date:  2021-03-31       Impact factor: 4.157

Review 4.  Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products.

Authors:  Islamudin Ahmad; Wisnu Cahyo Prabowo; Muhammad Arifuddin; Jaka Fadraersada; Niken Indriyanti; Herman Herman; Reza Yuridian Purwoko; Firzan Nainu; Anton Rahmadi; Swandari Paramita; Hadi Kuncoro; Nur Mita; Angga Cipta Narsa; Fajar Prasetya; Arsyik Ibrahim; Laode Rijai; Gemini Alam; Abdul Mun'im; Sukanya Dej-Adisai
Journal:  Life (Basel)       Date:  2022-01-27
  4 in total

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