Tomonori Yano1, Noriaki Hasuike2, Hiroyuki Ono3, Narikazu Boku4, Gakuto Ogawa5, Tomohiro Kadota6,5, Ichiro Oda7, Hisashi Doyama8, Shinichiro Hori9, Hiroyasu Iishi10, Akiko Takahashi11, Kohei Takizawa3, Manabu Muto12. 1. Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, 277-8577, Japan. toyano@east.ncc.go.jp. 2. Hasuike Clinic, Kobe, Japan. 3. Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan. 4. Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan. 5. JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan. 6. Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, 277-8577, Japan. 7. Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan. 8. Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan. 9. Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan. 10. Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan. 11. Department of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan. 12. Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Abstract
BACKGROUND: There are few reports on the technical difficulty of gastric endoscopic submucosal dissection (ESD). The aim of this study was to investigate the factors associated with the technical difficulty of ESD for early gastric cancer (EGC) using the data from the multicenter non-randomized confirmatory trial of expanded indication criteria of ESD (JCOG0607). METHODS: The major inclusion criteria were as follows: (1) histologically proven intestinal-type adenocarcinoma; (2) cT1aN0M0; (3) lesion without finding of ulcer (UL-negative) with > 2 cm in size, or UL-positive with ≤ 3 cm; (4) age 20-75 years. The difficult case was defined as ESD taking ≥ 120 min, piecemeal resection, and/or developing perforation during procedure. RESULTS: Between June 2007 and October 2010, 470 patients were enrolled from 29 institutions. Median procedure time was 79 (range 14-462) min, and it was ≥ 120 min in 127 patients. Twelve patients developed perforation during ESD, and the procedure time was ≥ 120 min in 9 of them. Therefore, 130 patients (27.7%) were identified as difficult cases. Multivariable analysis showed that UL-negative with > 5 cm (vs. UL-negative with ≤ 3 cm, odds ratio, 24.993; 95% CI 6.130-101.897, p < 0.0001) had the largest odds ratio and followed by UL-negative with 3-5 cm upper or middle portion of stomach and age ≤ 60 years were significantly associated with difficulty. CONCLUSIONS: UL-negative lesion with > 3 cm, upper or middle portion of stomach and age ≤ 60 years were independent factors associated with technical difficulty of ESD for EGC. Trial registered number was UMIN000000737.
BACKGROUND: There are few reports on the technical difficulty of gastric endoscopic submucosal dissection (ESD). The aim of this study was to investigate the factors associated with the technical difficulty of ESD for early gastric cancer (EGC) using the data from the multicenter non-randomized confirmatory trial of expanded indication criteria of ESD (JCOG0607). METHODS: The major inclusion criteria were as follows: (1) histologically proven intestinal-type adenocarcinoma; (2) cT1aN0M0; (3) lesion without finding of ulcer (UL-negative) with > 2 cm in size, or UL-positive with ≤ 3 cm; (4) age 20-75 years. The difficult case was defined as ESD taking ≥ 120 min, piecemeal resection, and/or developing perforation during procedure. RESULTS: Between June 2007 and October 2010, 470 patients were enrolled from 29 institutions. Median procedure time was 79 (range 14-462) min, and it was ≥ 120 min in 127 patients. Twelve patients developed perforation during ESD, and the procedure time was ≥ 120 min in 9 of them. Therefore, 130 patients (27.7%) were identified as difficult cases. Multivariable analysis showed that UL-negative with > 5 cm (vs. UL-negative with ≤ 3 cm, odds ratio, 24.993; 95% CI 6.130-101.897, p < 0.0001) had the largest odds ratio and followed by UL-negative with 3-5 cm upper or middle portion of stomach and age ≤ 60 years were significantly associated with difficulty. CONCLUSIONS: UL-negative lesion with > 3 cm, upper or middle portion of stomach and age ≤ 60 years were independent factors associated with technical difficulty of ESD for EGC. Trial registered number was UMIN000000737.
Entities:
Keywords:
Early gastric cancer; Endoscopic submucosal dissection; Technical difficulty
Authors: Ii-Kwun Chung; Jun Haeng Lee; Suck-Ho Lee; Sun-Joo Kim; Joo Young Cho; Won Young Cho; Young Hwangbo; Bo Ra Keum; Jong Jae Park; Hoon-Jai Chun; Hoi Jin Kim; Jae J Kim; Sam-Ryong Ji; Sang Young Seol Journal: Gastrointest Endosc Date: 2009-02-27 Impact factor: 9.427
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