M R Dauvermann1, G Donohoe1. 1. School of Psychology, National University of Ireland Galway, University Road, Galway, Ireland.
Abstract
OBJECTIVES: We review studies of whether cortisol levels following psychosocial stress exposure differ between patients with psychosis and healthy control subjects. METHODS: Original research published between 1993 and February 2019 was included in the literature search. Studies that used experimentally induced psychosocial stress and reported stress response measures of plasma or saliva cortisol levels in patients at any stage of illness (i.e. high risk, first episode and chronic phase) were included. RESULTS: A total of 17 studies were included. Although there was evidence of inconsistencies in measures, we observed moderate evidence of an association with stress-induced cortisol blunting response across studies. CONCLUSIONS: This review highlights recent evidence of blunting of cortisol response following experimentally induced psychosocial stress. While there was some evidence of this blunted response across illness types and stages, the strongest evidence was observed for those with chronic schizophrenia. Due to the low number of studies, in particular in bipolar disorder, much work is still needed to accurately characterise the biological effects of stress in psychosis.
OBJECTIVES: We review studies of whether cortisol levels following psychosocial stress exposure differ between patients with psychosis and healthy control subjects. METHODS: Original research published between 1993 and February 2019 was included in the literature search. Studies that used experimentally induced psychosocial stress and reported stress response measures of plasma or saliva cortisol levels in patients at any stage of illness (i.e. high risk, first episode and chronic phase) were included. RESULTS: A total of 17 studies were included. Although there was evidence of inconsistencies in measures, we observed moderate evidence of an association with stress-induced cortisol blunting response across studies. CONCLUSIONS: This review highlights recent evidence of blunting of cortisol response following experimentally induced psychosocial stress. While there was some evidence of this blunted response across illness types and stages, the strongest evidence was observed for those with chronic schizophrenia. Due to the low number of studies, in particular in bipolar disorder, much work is still needed to accurately characterise the biological effects of stress in psychosis.
Authors: Linda Rossini Gajšak; Željka Vogrinc; Mirela Čelić Ružić; Dina Bošnjak Kuharić; Marija Bošković; Ana Koričančić Makar; Porin Makarić; Vesna Ermakora; Ivana Kekin; Žarko Bajić; Martina Rojnić Kuzman Journal: Croat Med J Date: 2021-02-28 Impact factor: 1.351
Authors: Mark Corcoran; Emma L Hawkins; Denis O'Hora; Heather C Whalley; Jeremy Hall; Stephen M Lawrie; Maria R Dauvermann Journal: Brain Behav Date: 2020-05-09 Impact factor: 2.708
Authors: Yann Quidé; Leonardo Tozzi; Mark Corcoran; Dara M Cannon; Maria R Dauvermann Journal: Neuropsychiatr Dis Treat Date: 2020-12-14 Impact factor: 2.570
Authors: Andrei V Tarasov; Rofail S Rakhmanov; Elena S Bogomolova; Ludmila A Perminova; Zhanna L Malakhova Journal: Nutrients Date: 2021-06-20 Impact factor: 5.717
Authors: Vadim Tseilikman; Maria Komelkova; Marina V Kondashevskaya; Eugenia Manukhina; H Fred Downey; Valerii Chereshnev; Margarita Chereshneva; Pavel Platkovskii; Anna Goryacheva; Anton Pashkov; Julia Fedotova; Olga Tseilikman; Natalya Maltseva; Olga Cherkasova; Charlotte Steenblock; Stefan R Bornstein; Barbara Ettrich; George P Chrousos; Enrico Ullmann Journal: Int J Mol Sci Date: 2021-12-08 Impact factor: 5.923