Zechen Yan1, Dahai Yu2,3, Yamei Cai2, Jin Shang2, Rui Qin2, Jing Xiao2, Bin Zhao4, Zhanzheng Zhao5, David Simmons2,6. 1. Department of Urology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. 2. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. 3. Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom. 4. The Second Division of Internal Medicine, Kejing Community Health Centre, Jiyuan, China. 5. Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China, zhanzhengzhao@zzu.edu.cn. 6. Western Sydney University, Campbelltown, Sydney, New South Wales, Australia.
Abstract
BACKGROUND: Insulin resistance (IR) is increased among people with end-stage renal disease (ESRD). The Triglyceride glucose (TyG) index is a marker of IR and is also associated with the prognosis of cardiovascular disease among patients initiating peritoneal dialysis (PD). This study was aimed at examining the associations between TyG index and cardiovascular deaths in patients initiating PD. METHODS AND RESULTS: Three thousand fifty-four patients initiating PD between 2007 and 2014 were included in a prospective cohort derived from Henan PD Registry, TyG index alongside other baseline characteristics were measured when ESRD patients initiated PD. Logistic regression adjusting for age, gender, and major cardiovascular risk factors estimated the association between TyG index and subsequent cardiovascular mortality within 2 years since the initiation of PD. RESULTS: TyG index was positively associated with cardiovascular mortality: adjusted incidence rates ratio (95% CI) comparing the highest vs. lowest TyG index quartile was 2.32 (2.12-2.55) in all, 2.22 (2.01-2.46) in those with body mass index (BMI) <25 kg/m2, and 2.82 (2.24-3.54) in those with BMI ≥25 kg/m2, respectively. Linear dose-response relationships were revealed in all and by BMI. CONCLUSIONS: TyG index might be a prognostic factor in predicting cardiovascular mortality among patients initiating PD.
BACKGROUND:Insulin resistance (IR) is increased among people with end-stage renal disease (ESRD). The Triglycerideglucose (TyG) index is a marker of IR and is also associated with the prognosis of cardiovascular disease among patients initiating peritoneal dialysis (PD). This study was aimed at examining the associations between TyG index and cardiovascular deaths in patients initiating PD. METHODS AND RESULTS: Three thousand fifty-four patients initiating PD between 2007 and 2014 were included in a prospective cohort derived from Henan PD Registry, TyG index alongside other baseline characteristics were measured when ESRDpatients initiated PD. Logistic regression adjusting for age, gender, and major cardiovascular risk factors estimated the association between TyG index and subsequent cardiovascular mortality within 2 years since the initiation of PD. RESULTS:TyG index was positively associated with cardiovascular mortality: adjusted incidence rates ratio (95% CI) comparing the highest vs. lowest TyG index quartile was 2.32 (2.12-2.55) in all, 2.22 (2.01-2.46) in those with body mass index (BMI) <25 kg/m2, and 2.82 (2.24-3.54) in those with BMI ≥25 kg/m2, respectively. Linear dose-response relationships were revealed in all and by BMI. CONCLUSIONS:TyG index might be a prognostic factor in predicting cardiovascular mortality among patients initiating PD.
Authors: Borja Quiroga; Patricia Muñoz Ramos; Ana Sánchez Horrillo; Alberto Ortiz; José Manuel Valdivieso; Juan Jesús Carrero Journal: Clin Kidney J Date: 2022-03-10