Literature DB >> 31311817

Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemia.

Yoshihiro Gocho1,2, Jun J Yang1,2,3.   

Abstract

Recent genome-wide studies have revealed a plethora of germline variants that significantly influence the susceptibility to acute lymphoblastic leukemia (ALL), thus providing compelling evidence for genetic inheritance of this blood cancer. In particular, hematopoietic transcription factors (eg, ETV6, PAX5, IKZF1) are most frequently implicated in familial ALL, and germline variants in these genes confer strong predisposition (albeit with incomplete penetrance). Studies of germline risk factors for ALL provide unique insights into the molecular etiology of this leukemia.
© 2019 by The American Society of Hematology.

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Year:  2019        PMID： 31311817      PMCID： PMC6729010          DOI： 10.1182/blood.2018852400

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  59 in total

1.  Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.

Authors:  W Yu; H Nagaoka; M Jankovic; Z Misulovin; H Suh; A Rolink; F Melchers; E Meffre; M C Nussenzweig
Journal:  Nature       Date:  1999-08-12       Impact factor: 49.962

Review 2.  Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group.

Authors:  Christian Peter Kratz; Martin Stanulla; Hélène Cavé
Journal:  Eur J Med Genet       Date:  2015-12-15       Impact factor: 2.708

Review 3.  Acute lymphoblastic leukemia: monitoring minimal residual disease as a therapeutic principle.

Authors:  Monika Brüggemann; Nicola Gökbuget; Michael Kneba
Journal:  Semin Oncol       Date:  2012-02       Impact factor: 4.929

4.  A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia.

Authors:  Sohela Shah; Kasmintan A Schrader; Esmé Waanders; Andrew E Timms; Joseph Vijai; Cornelius Miething; John T Sandlund; Marshall S Horwitz; Charles G Mullighan; Kenneth Offit; Jeremy Wechsler; Jun Yang; James Hayes; Robert J Klein; Jinghui Zhang; Lei Wei; Gang Wu; Michael Rusch; Panduka Nagahawatte; Jing Ma; Shann-Ching Chen; Guangchun Song; Jinjun Cheng; Paul Meyers; Deepa Bhojwani; Suresh Jhanwar; Peter Maslak; Martin Fleisher; Jason Littman; Lily Offit; Rohini Rau-Murthy; Megan Harlan Fleischut; Marina Corines; Rajmohan Murali; Xiaoni Gao; Christopher Manschreck; Thomas Kitzing; Vundavalli V Murty; Susana Raimondi; Roland P Kuiper; Annet Simons; Joshua D Schiffman; Kenan Onel; Sharon E Plon; David Wheeler; Deborah Ritter; David S Ziegler; Kathy Tucker; Rosemary Sutton; Georgia Chenevix-Trench; Jun Li; David G Huntsman; Samantha Hansford; Janine Senz; Thomas Walsh; Ming Lee; Christopher N Hahn; Kathryn Roberts; Mary-Claire King; Sarah M Lo; Ross L Levine; Agnes Viale; Nicholas D Socci; Katherine L Nathanson; Hamish S Scott; Mark Daly; Steven M Lipkin; Scott W Lowe; James R Downing; David Altshuler
Journal:  Nat Genet       Date:  2013-09-08       Impact factor: 38.330

5.  RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

Authors:  Elli Papaemmanuil; Inmaculada Rapado; Yilong Li; Nicola E Potter; David C Wedge; Jose Tubio; Ludmil B Alexandrov; Peter Van Loo; Susanna L Cooke; John Marshall; Inigo Martincorena; Jonathan Hinton; Gunes Gundem; Frederik W van Delft; Serena Nik-Zainal; David R Jones; Manasa Ramakrishna; Ian Titley; Lucy Stebbings; Catherine Leroy; Andrew Menzies; John Gamble; Ben Robinson; Laura Mudie; Keiran Raine; Sarah O'Meara; Jon W Teague; Adam P Butler; Giovanni Cazzaniga; Andrea Biondi; Jan Zuna; Helena Kempski; Markus Muschen; Anthony M Ford; Michael R Stratton; Mel Greaves; Peter J Campbell
Journal:  Nat Genet       Date:  2014-01-12       Impact factor: 38.330

Review 6.  The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia.

Authors:  Anthony V Moorman
Journal:  Blood Rev       Date:  2012-03-20       Impact factor: 8.250

7.  BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

Authors:  Charles G Mullighan; Christopher B Miller; Ina Radtke; Letha A Phillips; James Dalton; Jing Ma; Deborah White; Timothy P Hughes; Michelle M Le Beau; Ching-Hon Pui; Mary V Relling; Sheila A Shurtleff; James R Downing
Journal:  Nature       Date:  2008-04-13       Impact factor: 49.962

8.  Germline genomic variants associated with childhood acute lymphoblastic leukemia.

Authors:  Lisa R Treviño; Wenjian Yang; Deborah French; Stephen P Hunger; William L Carroll; Meenakshi Devidas; Cheryl Willman; Geoffrey Neale; James Downing; Susana C Raimondi; Ching-Hon Pui; William E Evans; Mary V Relling
Journal:  Nat Genet       Date:  2009-08-16       Impact factor: 38.330

9.  Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations.

Authors:  Akihiro Hoshino; Satoshi Okada; Kenichi Yoshida; Naonori Nishida; Yusuke Okuno; Hiroo Ueno; Motoi Yamashita; Tsubasa Okano; Miyuki Tsumura; Shiho Nishimura; Sonoko Sakata; Masao Kobayashi; Haruna Nakamura; Junji Kamizono; Kanako Mitsui-Sekinaka; Takuya Ichimura; Shouichi Ohga; Yozo Nakazawa; Masatoshi Takagi; Kohsuke Imai; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa; Seiji Kojima; Shigeaki Nonoyama; Tomohiro Morio; Hirokazu Kanegane
Journal:  J Allergy Clin Immunol       Date:  2016-12-06       Impact factor: 10.793

10.  Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.

Authors:  Srividya Swaminathan; Lars Klemm; Eugene Park; Elli Papaemmanuil; Anthony Ford; Soo-Mi Kweon; Daniel Trageser; Brian Hasselfeld; Nadine Henke; Jana Mooster; Huimin Geng; Klaus Schwarz; Scott C Kogan; Rafael Casellas; David G Schatz; Michael R Lieber; Mel F Greaves; Markus Müschen
Journal:  Nat Immunol       Date:  2015-05-18       Impact factor: 25.606
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  9 in total

1.  Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.

Authors:  Linda Kachuri; Soyoung Jeon; Andrew T DeWan; Catherine Metayer; Xiaomei Ma; John S Witte; Charleston W K Chiang; Joseph L Wiemels; Adam J de Smith
Journal:  Am J Hum Genet       Date:  2021-08-31       Impact factor: 11.043

Review 2.  Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia.

Authors:  Cesar Cobaleda; Carolina Vicente-Dueñas; Isidro Sanchez-Garcia
Journal:  Nat Rev Immunol       Date:  2021-02-08       Impact factor: 53.106

3.  Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia.

Authors:  Lauren Pommert; Robert Burns; Quinlan Furumo; Kirthi Pulakanti; Jon Brandt; Michael J Burke; Sridhar Rao
Journal:  Cancer Rep (Hoboken)       Date:  2021-01-27

Review 4.  The E-Twenty-Six Family in Hepatocellular Carcinoma: Moving into the Spotlight.

Authors:  Tongyue Zhang; Danfei Liu; Yijun Wang; Mengyu Sun; Limin Xia
Journal:  Front Oncol       Date:  2021-01-27       Impact factor: 6.244

5.  Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia.

Authors:  Suvi P M Douglas; Atte K Lahtinen; Jessica R Koski; Lilli Leimi; Mikko A I Keränen; Minna Koskenvuo; Caroline A Heckman; Kirsi Jahnukainen; Esa Pitkänen; Ulla Wartiovaara-Kautto; Outi Kilpivaara
Journal:  Sci Rep       Date:  2022-06-23       Impact factor: 4.996

Review 6.  Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and Leukemia.

Authors:  Ute Fischer; Jun J Yang; Tomokatsu Ikawa; Daniel Hein; Carolina Vicente-Dueñas; Arndt Borkhardt; Isidro Sánchez-García
Journal:  Blood Cancer Discov       Date:  2020-09-14

7.  PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.

Authors:  Ling Jin; Laigen Tong
Journal:  Immun Inflamm Dis       Date:  2021-05-06

Review 8.  Review of guidelines for the identification and clinical care of patients with genetic predisposition for hematological malignancies.

Authors:  Brigitte Schlegelberger; Cristina Mecucci; Marcin Wlodarski
Journal:  Fam Cancer       Date:  2021-05-31       Impact factor: 2.375

9.  Identification of Potential Signatures and Their Functions for Acute Lymphoblastic Leukemia: A Study Based on the Cancer Genome Atlas.

Authors:  Weimin Wang; Chunhui Lyu; Fei Wang; Congcong Wang; Feifei Wu; Xue Li; Silin Gan
Journal:  Front Genet       Date:  2021-07-06       Impact factor: 4.599
  9 in total

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