Özhan Pazarci1, Halef Okan Dogan2, Seyran Kilinc3, Yalkin Çamurcu4. 1. Department of Orthopedics and Traumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, dr.pazarci@gmail.com. 2. Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey. 3. Department of Orthopedics and Traumatology, Cumhuriyet University School of Medicine, Sivas, Turkey. 4. Department of Orthopedics and Traumatology, Erzincan University School of Medicine, Erzincan, Turkey.
Abstract
OBJECTIVES: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. MATERIALS AND METHODS: This study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups. RESULTS: Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1. CONCLUSION: Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.
OBJECTIVES: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. MATERIALS AND METHODS: This study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups. RESULTS: Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1. CONCLUSION: Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.
Authors: Michael F Holick; Neil C Binkley; Heike A Bischoff-Ferrari; Catherine M Gordon; David A Hanley; Robert P Heaney; M Hassan Murad; Connie M Weaver Journal: J Clin Endocrinol Metab Date: 2011-06-06 Impact factor: 5.958
Authors: Rachel M Thompson; Daniel M Dean; Sarah Goldberg; Mary J Kwasny; Craig B Langman; Joseph A Janicki Journal: J Pediatr Orthop Date: 2017-09 Impact factor: 2.324