Shouquan Wu1, Yu Wang2, Miaomiao Zhang3, Minggui Wang1, Jian-Qing He4. 1. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. 2. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: yuwang_westchina@163.com. 3. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: zhangmiaomiao0522@126.com. 4. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: jianqhe@gmail.com.
Abstract
BACKGROUND: Tuberculosis (TB) is the type of chronic infectious disease which majorly caused by Mycobacterium tuberculosis (M. TB). Emerging data suggest that interferon gamma (IFNG) and its receptor IFNGR1 may be involved in the risk of TB. METHODS: A total of 636 TB patients and 608 healthy controls were selected. The association between single nucleotide polymorphisms (SNPs) and TB was estimated by logistic analyses adjusting for age, gender and smoking status. SNPs genotyping was done by using the improved multiplex ligase detection reaction (iMLDR). RESULTS: The IFNG rs1861494 allele C was related to an increased risk for TB (OR = 1.25, 95%CI: 1.06-1.48; P = 0.009). Compared with TT genotype, CT (OR = 1.28, 95%CI: 1.01-1.63; P = 0.040) and CC (OR = 1.51, 95%CI: 1.04-2.19; P = 0.031) were also risk factors for TB. In the subgroup analysis, the association was stronger among participants < 25 years (OR = 2.40, 95%CI: 1.70-3.38; P < 0.001) and male groups (OR = 1.31, 95%CI: 1.03-1.66; P = 0.030). In addition, IFNG rs1861494 was associated with anti-TB treatment outcome (OR = 0.70, 95%CI: 0.52-0.94; P = 0.017). We also detected that IFNGR1 rs2234711 influenced the IFNG production. CONCLUSION: IFNG rs1861494 polymorphism was associated with TB, particularly in the younger and male subgroups.
BACKGROUND:Tuberculosis (TB) is the type of chronic infectious disease which majorly caused by Mycobacterium tuberculosis (M. TB). Emerging data suggest that interferon gamma (IFNG) and its receptor IFNGR1 may be involved in the risk of TB. METHODS: A total of 636 TB patients and 608 healthy controls were selected. The association between single nucleotide polymorphisms (SNPs) and TB was estimated by logistic analyses adjusting for age, gender and smoking status. SNPs genotyping was done by using the improved multiplex ligase detection reaction (iMLDR). RESULTS: The IFNGrs1861494 allele C was related to an increased risk for TB (OR = 1.25, 95%CI: 1.06-1.48; P = 0.009). Compared with TT genotype, CT (OR = 1.28, 95%CI: 1.01-1.63; P = 0.040) and CC (OR = 1.51, 95%CI: 1.04-2.19; P = 0.031) were also risk factors for TB. In the subgroup analysis, the association was stronger among participants < 25 years (OR = 2.40, 95%CI: 1.70-3.38; P < 0.001) and male groups (OR = 1.31, 95%CI: 1.03-1.66; P = 0.030). In addition, IFNGrs1861494 was associated with anti-TB treatment outcome (OR = 0.70, 95%CI: 0.52-0.94; P = 0.017). We also detected that IFNGR1rs2234711 influenced the IFNG production. CONCLUSION:IFNGrs1861494 polymorphism was associated with TB, particularly in the younger and male subgroups.
Authors: Tamiris Azamor; Andréa Marques Vieira da Silva; Juliana Gil Melgaço; Ana Paula Dos Santos; Caroline Xavier-Carvalho; Lucia Elena Alvarado-Arnez; Leonardo Ribeiro Batista-Silva; Denise Cristina de Souza Matos; Camilla Bayma; Sotiris Missailidis; Ana Paula Dinis Ano Bom; Milton Ozorio Moraes; Patrícia Cristina da Costa Neves Journal: Viruses Date: 2021-01-12 Impact factor: 5.048
Authors: Noha A Hassuna; Mohamed El Feky; Aliae A R Mohamed Hussein; Manal A Mahmoud; Naglaa K Idriss; Sayed F Abdelwahab; Maggie A Ibrahim Journal: PLoS One Date: 2021-01-07 Impact factor: 3.240