BACKGROUND: The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS: The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether baseline CDR scores were predictive of cognitive or functional decline and progression to dementia over 6 years. METHODS: At baseline, the sample comprised 733 non-demented participants aged 70-90 years from the longitudinal Sydney Memory and Ageing Study. Global and sum of boxes CDR scores were obtained at baseline. Participants also received comprehensive neuropsychological and functional assessment as well as expert consensus diagnoses at baseline and follow-up. RESULTS: At baseline, CDR scores had high specificity but low sensitivity for broadly defined MCI. The balance of sensitivity and specificity improved for narrowly defined MCI. Longitudinally, all baseline CDR scores predicted functional change and dementia, but CDR scores were not predictive of cognitive change. CONCLUSION: CDR scores do not correspond well with MCI, except when MCI is narrowly defined, suggesting that the CDR taps into the more severe end of MCI. All CDR scores usefully predict functional decline and incident dementia.
BACKGROUND: The Clinical Dementia Rating Scale (CDR) is used to rate dementia severity. Its utility in diagnosing mild cognitive impairment (MCI) and its predictive value remain unknown. AIMS: The aim of this study was to examine the association between CDR scores and expert MCI diagnosis, and to determine whether baseline CDR scores were predictive of cognitive or functional decline and progression to dementia over 6 years. METHODS: At baseline, the sample comprised 733 non-demented participants aged 70-90 years from the longitudinal Sydney Memory and Ageing Study. Global and sum of boxes CDR scores were obtained at baseline. Participants also received comprehensive neuropsychological and functional assessment as well as expert consensus diagnoses at baseline and follow-up. RESULTS: At baseline, CDR scores had high specificity but low sensitivity for broadly defined MCI. The balance of sensitivity and specificity improved for narrowly defined MCI. Longitudinally, all baseline CDR scores predicted functional change and dementia, but CDR scores were not predictive of cognitive change. CONCLUSION: CDR scores do not correspond well with MCI, except when MCI is narrowly defined, suggesting that the CDR taps into the more severe end of MCI. All CDR scores usefully predict functional decline and incident dementia.
Authors: Nilton Custodio; Rosa Montesinos; Monica M Diaz; Eder Herrera-Perez; Kristhy Chavez; Carlos Alva-Diaz; Willyams Reynoso-Guzman; Maritza Pintado-Caipa; José Cuenca; Carlos Gamboa; Serggio Lanata Journal: Front Neurol Date: 2021-07-07 Impact factor: 4.003
Authors: Maria C Duggan; Madeline E Morrell; Rameela Chandrasekhar; Annachiara Marra; Kwame Frimpong; Deepanjali R Nair; Timothy D Girard; Pratik P Pandharipande; E Wesley Ely; James C Jackson Journal: Dement Geriatr Cogn Disord Date: 2020-04-07 Impact factor: 3.346
Authors: Sarah Morgan; Sarah Kellner; Jesus Gutierrez; Kathleen Collins; Brittany Rohl; Fanny Migliore; Stephanie Cosentino; Edward D Huey; Elan D Louis; Joan K Monin Journal: Front Neurol Date: 2017-08-14 Impact factor: 4.003
Authors: Yvonne Höller; Kevin H G Butz; Aljoscha C Thomschewski; Elisabeth V Schmid; Christoph D Hofer; Andreas Uhl; Arne C Bathke; Wolfgang Staffen; Raffaele Nardone; Fabian Schwimmbeck; Markus Leitinger; Giorgi Kuchukhidze; Marlene Derner; Jürgen Fell; Eugen Trinka Journal: Comput Intell Neurosci Date: 2020-05-20
Authors: Muriel M K Bruchhage; Stephen Correia; Paul Malloy; Stephen Salloway; Sean Deoni Journal: Front Aging Neurosci Date: 2020-11-03 Impact factor: 5.750