Yong Wang1, Jing Chen2, Rui Zhao1, Lin Xia1, Ya-Ping Cui1, Zhi-Yong Rao3, Yong Zhou4, Xiao-Ting Wu5. 1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China. 2. Healthcare-Associated Infection Control Center, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, China. 3. Department of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu, China. 4. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China. nutritioner@hotmail.com. 5. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China. wxt1@medmail.com.cn.
Abstract
BACKGROUND: The association between coffee and colorectal adenoma risk remains controversial. We conducted a meta-analysis of cohort and case-control studies to sum up the existing proof about this matter. METHODS: We searched Pubmed, Medline, and Embase for studies published before 1 September 2018 on coffee consumption and colorectal adenoma in any language. The different ORs were calculated for cohort and case-control studies in this study, and we use a random-effects model to aggregate the relative risks of individual studies and conduct dose response, heterogeneity, and publication bias. RESULTS: A total of 8 studies (6 case-control studies, 2 cohort studies) were identified, including 7090 subjects. In a summary analysis of all studies, high coffee intake (compared the highest with the lowest categories) was associated with a reduced risk of colorectal adenoma (odds ratio [OR] = 0.70, 95% confidence interval [CI] = 0.55-0.90). The results of subgroup analysis of adenoma location were similar with the pooled analysis, except for rectal adenoma. In the dose-response meta-analysis study, the estimated total odds ratio for increasing coffee consumption by 150 ml per day (about one cup) was 0.91 (95% CI = 0.87-0.95). CONCLUSIONS: The meta-analysis demonstrates possible evidence that increased coffee intake is related to a reduced risk of colon adenoma. However, because of latent confusion and different exposure classification, this finding should be carefully considered.
BACKGROUND: The association between coffee and colorectal adenoma risk remains controversial. We conducted a meta-analysis of cohort and case-control studies to sum up the existing proof about this matter. METHODS: We searched Pubmed, Medline, and Embase for studies published before 1 September 2018 on coffee consumption and colorectal adenoma in any language. The different ORs were calculated for cohort and case-control studies in this study, and we use a random-effects model to aggregate the relative risks of individual studies and conduct dose response, heterogeneity, and publication bias. RESULTS: A total of 8 studies (6 case-control studies, 2 cohort studies) were identified, including 7090 subjects. In a summary analysis of all studies, high coffee intake (compared the highest with the lowest categories) was associated with a reduced risk of colorectal adenoma (odds ratio [OR] = 0.70, 95% confidence interval [CI] = 0.55-0.90). The results of subgroup analysis of adenoma location were similar with the pooled analysis, except for rectal adenoma. In the dose-response meta-analysis study, the estimated total odds ratio for increasing coffee consumption by 150 ml per day (about one cup) was 0.91 (95% CI = 0.87-0.95). CONCLUSIONS: The meta-analysis demonstrates possible evidence that increased coffee intake is related to a reduced risk of colon adenoma. However, because of latent confusion and different exposure classification, this finding should be carefully considered.
Authors: Xuehong Zhang; Demetrius Albanes; W Lawrence Beeson; Piet A van den Brandt; Julie E Buring; Andrew Flood; Jo L Freudenheim; Edward L Giovannucci; R Alexandra Goldbohm; Karen Jaceldo-Siegl; Eric J Jacobs; Vittorio Krogh; Susanna C Larsson; James R Marshall; Marjorie L McCullough; Anthony B Miller; Kim Robien; Thomas E Rohan; Arthur Schatzkin; Sabina Sieri; Donna Spiegelman; Jarmo Virtamo; Alicja Wolk; Walter C Willett; Shumin M Zhang; Stephanie A Smith-Warner Journal: J Natl Cancer Inst Date: 2010-05-07 Impact factor: 13.506
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