Jimi Kim1, Jeonghee Lee1, Jae Hwan Oh2, Hee Jin Chang2, Dae Kyung Sohn2, Aesun Shin3, Jeongseon Kim4. 1. Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, South Korea. 2. Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, South Korea. 3. Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. 4. Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, South Korea. jskim@ncc.re.kr.
Abstract
PURPOSE: The effects of seaweed compounds have been studied in relation to colorectal cancer (CRC) based on their ability to modulate carcinogen metabolism in vivo and in vitro. However, no epidemiological studies on the interaction between edible seaweed and genetic variants relevant to CRC have been reported. This study examined the associations among dietary seaweed intake (gim, miyeok, and dashima), single-nucleotide polymorphisms (SNPs; rs6983267, rs7014346, and rs719725), and CRC risk in a Korean population. METHODS: The participants comprised 923 CRC patients and 1846 controls who visited the National Cancer Center Korea. We used a Semiquantitative Food Frequency Questionnaire and genotyped SNPs using genomic DNA samples. RESULTS: The intake of total seaweed, miyeok, and dashima showed a significant inverse association with CRC risk after adjusting for potential confounding factors (total seaweed odds ratio (OR) [95% CI] = 0.65 [0.50-0.85], P for trend < 0.001; miyeok = 0.82 [0.62-1.09], P for trend < 0.05; dashima = 0.58 [0.44-0.76], P for trend < 0.001, highest vs. lowest tertile). We confirmed that the homozygous T/T allele of rs6983267 c-MYC indicated an interaction between dietary seaweed intake and both overall CRC and rectal cancer (CRC OR [95% CI] = 0.52 [0.34-0.81], P for interaction = 0.015; rectal cancer = 0.45 [0.25-0.79], P for interaction = 0.007, T/T carriers with high total seaweed intake vs. T/T carriers with low total seaweed intake). CONCLUSIONS: This study provides evidence of the effect of dietary seaweed intake on CRC risk with respect to c-MYC gene variants.
PURPOSE: The effects of seaweed compounds have been studied in relation to colorectal cancer (CRC) based on their ability to modulate carcinogen metabolism in vivo and in vitro. However, no epidemiological studies on the interaction between edible seaweed and genetic variants relevant to CRC have been reported. This study examined the associations among dietary seaweed intake (gim, miyeok, and dashima), single-nucleotide polymorphisms (SNPs; rs6983267, rs7014346, and rs719725), and CRC risk in a Korean population. METHODS: The participants comprised 923 CRC patients and 1846 controls who visited the National Cancer Center Korea. We used a Semiquantitative Food Frequency Questionnaire and genotyped SNPs using genomic DNA samples. RESULTS: The intake of total seaweed, miyeok, and dashima showed a significant inverse association with CRC risk after adjusting for potential confounding factors (total seaweed odds ratio (OR) [95% CI] = 0.65 [0.50-0.85], P for trend < 0.001; miyeok = 0.82 [0.62-1.09], P for trend < 0.05; dashima = 0.58 [0.44-0.76], P for trend < 0.001, highest vs. lowest tertile). We confirmed that the homozygous T/T allele of rs6983267 c-MYC indicated an interaction between dietary seaweed intake and both overall CRC and rectal cancer (CRC OR [95% CI] = 0.52 [0.34-0.81], P for interaction = 0.015; rectal cancer = 0.45 [0.25-0.79], P for interaction = 0.007, T/T carriers with high total seaweed intake vs. T/T carriers with low total seaweed intake). CONCLUSIONS: This study provides evidence of the effect of dietary seaweed intake on CRC risk with respect to c-MYC gene variants.
Authors: Albert Tenesa; Susan M Farrington; James G D Prendergast; Mary E Porteous; Marion Walker; Naila Haq; Rebecca A Barnetson; Evropi Theodoratou; Roseanne Cetnarskyj; Nicola Cartwright; Colin Semple; Andrew J Clark; Fiona J L Reid; Lorna A Smith; Kostas Kavoussanakis; Thibaud Koessler; Paul D P Pharoah; Stephan Buch; Clemens Schafmayer; Jürgen Tepel; Stefan Schreiber; Henry Völzke; Carsten O Schmidt; Jochen Hampe; Jenny Chang-Claude; Michael Hoffmeister; Hermann Brenner; Stefan Wilkening; Federico Canzian; Gabriel Capella; Victor Moreno; Ian J Deary; John M Starr; Ian P M Tomlinson; Zoe Kemp; Kimberley Howarth; Luis Carvajal-Carmona; Emily Webb; Peter Broderick; Jayaram Vijayakrishnan; Richard S Houlston; Gad Rennert; Dennis Ballinger; Laura Rozek; Stephen B Gruber; Koichi Matsuda; Tomohide Kidokoro; Yusuke Nakamura; Brent W Zanke; Celia M T Greenwood; Jagadish Rangrej; Rafal Kustra; Alexandre Montpetit; Thomas J Hudson; Steven Gallinger; Harry Campbell; Malcolm G Dunlop Journal: Nat Genet Date: 2008-03-30 Impact factor: 38.330
Authors: Emma S Brown; Philip J Allsopp; Pamela J Magee; Chris I R Gill; Sonja Nitecki; Conall R Strain; Emeir M McSorley Journal: Nutr Rev Date: 2014-03 Impact factor: 7.110
Authors: Jenny N Poynter; Jane C Figueiredo; David V Conti; Kathleen Kennedy; Steven Gallinger; Kimberly D Siegmund; Graham Casey; Stephen N Thibodeau; Mark A Jenkins; John L Hopper; Graham B Byrnes; John A Baron; Ellen L Goode; Maarit Tiirikainen; Noralane Lindor; John Grove; Polly Newcomb; Jeremy Jass; Joanne Young; John D Potter; Robert W Haile; David J Duggan; Loic Le Marchand Journal: Cancer Res Date: 2007-12-01 Impact factor: 12.701
Authors: Brent W Zanke; Celia M T Greenwood; Jagadish Rangrej; Rafal Kustra; Albert Tenesa; Susan M Farrington; James Prendergast; Sylviane Olschwang; Theodore Chiang; Edgar Crowdy; Vincent Ferretti; Philippe Laflamme; Saravanan Sundararajan; Stéphanie Roumy; Jean-François Olivier; Frédérick Robidoux; Robert Sladek; Alexandre Montpetit; Peter Campbell; Stephane Bezieau; Anne Marie O'Shea; George Zogopoulos; Michelle Cotterchio; Polly Newcomb; John McLaughlin; Ban Younghusband; Roger Green; Jane Green; Mary E M Porteous; Harry Campbell; Helene Blanche; Mourad Sahbatou; Emmanuel Tubacher; Catherine Bonaiti-Pellié; Bruno Buecher; Elio Riboli; Sebastien Kury; Stephen J Chanock; John Potter; Gilles Thomas; Steven Gallinger; Thomas J Hudson; Malcolm G Dunlop Journal: Nat Genet Date: 2007-07-08 Impact factor: 38.330
Authors: Ian Tomlinson; Emily Webb; Luis Carvajal-Carmona; Peter Broderick; Zoe Kemp; Sarah Spain; Steven Penegar; Ian Chandler; Maggie Gorman; Wendy Wood; Ella Barclay; Steven Lubbe; Lynn Martin; Gabrielle Sellick; Emma Jaeger; Richard Hubner; Ruth Wild; Andrew Rowan; Sarah Fielding; Kimberley Howarth; Andrew Silver; Wendy Atkin; Kenneth Muir; Richard Logan; David Kerr; Elaine Johnstone; Oliver Sieber; Richard Gray; Huw Thomas; Julian Peto; Jean-Baptiste Cazier; Richard Houlston Journal: Nat Genet Date: 2007-07-08 Impact factor: 38.330
Authors: Laura A E Hughes; Colinda C J M Simons; Piet A van den Brandt; Manon van Engeland; Matty P Weijenberg Journal: Curr Colorectal Cancer Rep Date: 2017-12-02