Literature DB >> 31299197

Senescence Evasion in Chemotherapy: A Sweet Spot for p21.

Humza M Ashraf1, Justin Moser1, Sabrina L Spencer2.   

Abstract

Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31299197      PMCID： PMC6805149          DOI： 10.1016/j.cell.2019.06.025

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

Review 1.  Forging a signature of in vivo senescence.

Authors:  Norman E Sharpless; Charles J Sherr
Journal:  Nat Rev Cancer       Date:  2015-07       Impact factor: 60.716

2.  Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells.

Authors:  Mansi Arora; Justin Moser; Harsha Phadke; Ashik Akbar Basha; Sabrina L Spencer
Journal:  Cell Rep       Date:  2017-05-16       Impact factor: 9.423

3.  Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.

Authors:  Tatsiana Ryl; Erika E Kuchen; Emma Bell; Chunxuan Shao; Andrés F Flórez; Gregor Mönke; Sina Gogolin; Mona Friedrich; Florian Lamprecht; Frank Westermann; Thomas Höfer
Journal:  Cell Syst       Date:  2017-08-23       Impact factor: 10.304

4.  Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.

Authors:  H E Skipper; F M Schabel; L B Mellett; J A Montgomery; L J Wilkoff; H H Lloyd; R W Brockman
Journal:  Cancer Chemother Rep       Date:  1970-12

5.  Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy.

Authors:  Chien-Hsiang Hsu; Steven J Altschuler; Lani F Wu
Journal:  Cell       Date:  2019-06-13       Impact factor: 41.582

6.  A Cell-Cycle "Safe Space" for Surviving Chemotherapy.

Authors:  Mansi Arora; Sabrina L Spencer
Journal:  Cell Syst       Date:  2017-09-27       Impact factor: 10.304

7.  Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Authors:  José Reyes; Jia-Yun Chen; Jacob Stewart-Ornstein; Kyle W Karhohs; Caroline S Mock; Galit Lahav
Journal:  Mol Cell       Date:  2018-07-26       Impact factor: 17.970

Review 8.  p21 in cancer: intricate networks and multiple activities.

Authors:  Tarek Abbas; Anindya Dutta
Journal:  Nat Rev Cancer       Date:  2009-06       Impact factor: 60.716

9.  Control of the Restriction Point by Rb and p21.

Authors:  Justin Moser; Iain Miller; Dylan Carter; Sabrina L Spencer
Journal:  Proc Natl Acad Sci U S A       Date:  2018-08-15       Impact factor: 11.205

10.  Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence.

Authors:  Gabriel E Neurohr; Rachel L Terry; Jette Lengefeld; Megan Bonney; Gregory P Brittingham; Fabien Moretto; Teemu P Miettinen; Laura Pontano Vaites; Luis M Soares; Joao A Paulo; J Wade Harper; Stephen Buratowski; Scott Manalis; Folkert J van Werven; Liam J Holt; Angelika Amon
Journal:  Cell       Date:  2019-02-07       Impact factor: 41.582
  10 in total
  5 in total

1.  TAS-102 has a tumoricidal activity in multiple myeloma.

Authors:  Guoli Li; Huan Liu; Jin He; Zongwei Li; Zhiming Wang; Shan Zhou; Guopei Zheng; Zhimin He; Jing Yang
Journal:  Am J Cancer Res       Date:  2020-11-01       Impact factor: 5.942

2.  Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4-pRB Axis in Fibroblasts at the Invasive Tumor Edge.

Authors:  Gina Bouchard; Fernando Jose Garcia-Marques; Loukia Georgiou Karacosta; Weiruo Zhang; Abel Bermudez; Nicholas McIlvain Riley; Sushama Varma; Lindsey Catherine Mehl; Jalen Anthony Benson; Joseph B Shrager; Carolyn Ruth Bertozzi; Sharon J Pitteri; Amato J Giaccia; Sylvia Katina Plevritis
Journal:  Cancer Res       Date:  2022-02-15       Impact factor: 13.312

3.  Differential sensitivity of renal carcinoma cells to doxorubicin and epigenetic therapeutics depends on the genetic background.

Authors:  Narayan Acharya; Kamaleshwar P Singh
Journal:  Mol Cell Biochem       Date:  2021-02-16       Impact factor: 3.396

4.  MBNL2 Regulates DNA Damage Response via Stabilizing p21.

Authors:  Jin Cai; Ningchao Wang; Guanglan Lin; Haowei Zhang; Weidong Xie; Yaou Zhang; Naihan Xu
Journal:  Int J Mol Sci       Date:  2021-01-14       Impact factor: 5.923

Review 5.  The redox-senescence axis and its therapeutic targeting.

Authors:  Natalie Yl Ngoi; Angeline Qx Liew; Stephen J F Chong; Matthew S Davids; Marie-Veronique Clement; Shazib Pervaiz
Journal:  Redox Biol       Date:  2021-06-05       Impact factor: 11.799
  5 in total

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