Literature DB >> 31285291

Severe T2-high asthma in the biologics era: European experts' opinion.

Ian Pavord1, Thomas Bahmer2, Fulvio Braido3, Borja G Cosío4,5, Marc Humbert6,7, Marco Idzko8, Lukasz Adamek9.   

Abstract

The European Respiratory Biologics Forum gathered participants from 21 countries in Madrid, Spain, to discuss the management and treatment of severe asthma in the era of biologics. The current insights on the pathophysiology of severe asthma were discussed, as well as the role of respiratory biologics in clinical practice and strategies for eliminating chronic use of oral corticosteroids. The participants also highlighted the key challenges in identifying patients with severe asthma based on phenotypes, biomarkers and treatable traits, and the existing problems in patient referral to specialist care. The monitoring of treatment was debated and the need for a change towards precision medicine and personalised care was emphasised throughout the meeting. This review provides a summary of the discussions and highlights important concerns identified by the participants regarding the current management of severe asthma.
Copyright ©ERS 2019.

Entities:  

Year:  2019        PMID: 31285291     DOI: 10.1183/16000617.0054-2019

Source DB:  PubMed          Journal:  Eur Respir Rev        ISSN: 0905-9180


  10 in total

1.  Treatment options in type-2 low asthma.

Authors:  Timothy S C Hinks; Stewart J Levine; Guy G Brusselle
Journal:  Eur Respir J       Date:  2021-01-21       Impact factor: 16.671

Review 2.  Small Airway Disease in Pediatric Asthma: the Who, What, When, Where, Why, and How to Remediate. A Review and Commentary.

Authors:  Russell J Hopp; Mark C Wilson; M Asghar Pasha
Journal:  Clin Rev Allergy Immunol       Date:  2020-11-26       Impact factor: 8.667

3.  Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma.

Authors:  Yumei Zhou; Tieshan Wang; Xiaoshan Zhao; Ji Wang; Qi Wang
Journal:  Front Pharmacol       Date:  2022-05-18       Impact factor: 5.988

Review 4. 

Authors:  Adrian Gillissen
Journal:  Pneumo News       Date:  2022-05-03

5.  Effects of anti-IL5 biological treatments on blood IgE levels in severe asthmatic patients: A real-life multicentre study (BIONIGE).

Authors:  Marco Contoli; Pierachille Santus; Francesco Menzella; Cindy Rocchi; Dejan Radovanovic; Federico Baraldi; Chiara Martelli; Serena Casanova; Carlo Barbetta; Claudio Micheletto; Nicola Scichilone; Bianca Beghè; Elisiana Carpagnano; Alberto Papi
Journal:  Clin Transl Allergy       Date:  2022-04-07       Impact factor: 5.657

Review 6.  Sex Steroids Effects on Asthma: A Network Perspective of Immune and Airway Cells.

Authors:  Niyati A Borkar; Colin Kelly Combs; Venkatachalem Sathish
Journal:  Cells       Date:  2022-07-19       Impact factor: 7.666

7.  DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.

Authors:  Kevin M Magnaye; Selene M Clay; Jessie Nicodemus-Johnson; Katherine A Naughton; Janel Huffman; Matthew C Altman; Daniel J Jackson; James E Gern; Douglas K Hogarth; Edward T Naureckas; Steven R White; Carole Ober
Journal:  Proc Natl Acad Sci U S A       Date:  2022-06-06       Impact factor: 12.779

Review 8.  Biomarkers in Different Asthma Phenotypes.

Authors:  Sanja Popović-Grle; Anamarija Štajduhar; Marina Lampalo; Dina Rnjak
Journal:  Genes (Basel)       Date:  2021-05-25       Impact factor: 4.096

9.  Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma.

Authors:  Katherina B Sreter; Sanja Popovic-Grle; Marina Lampalo; Marcela Konjevod; Lucija Tudor; Matea Nikolac Perkovic; Irena Jukic; Jasna Bingulac-Popovic; Hana Safic Stanic; Jasenka Markeljevic; Nela Pivac; Dubravka Svob Strac
Journal:  J Pers Med       Date:  2020-10-24

Review 10.  Treating severe asthma: Targeting the IL-5 pathway.

Authors:  Stefania Principe; Celeste Porsbjerg; Sisse Bolm Ditlev; Ditte Kjaersgaard Klein; Korneliusz Golebski; Nanna Dyhre-Petersen; Yoni E van Dijk; Job J M H van Bragt; Lente L H Dankelman; Sven-Erik Dahlen; Christopher E Brightling; Susanne J H Vijverberg; Anke H Maitland-van der Zee
Journal:  Clin Exp Allergy       Date:  2021-05-21       Impact factor: 5.018

  10 in total

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