Jakrin Kewcharoen1, Elysse S Tom2, Chonlanan Wiboonchutikula3, Angkawipa Trongtorsak4, Chutikarn Wittayalikit4, Wasawat Vutthikraivit5, Narut Prasitlumkum1, Pattara Rattanawong6,7. 1. Department of Medicine, University of Hawaii Internal Medicine Residency Program, Honolulu, Hawaii, USA. 2. Ophthalmology Department, University of Washington, Seattle, Washington, USA. 3. Faculty of Medicine, Thammasat University, Bangkok, Thailand. 4. Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand. 5. Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA. 6. Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 7. Department of Cardiovascular Diseases, Mayo Clinic, Phoenix, Arizona, USA.
Abstract
Objective: Recent studies have shown that atrial fibrillation (AF) is more prevalent in patients with retinal vessel occlusion and may be associated with both central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO). However, there is no systematic review and meta-analysis to confirm this finding. Methods: We searched the databases of MEDLINE and EMBASE from inception to January 2019. Included studies were published cohort, case-control or cross-sectional studies, and randomized control trials reporting the prevalence of AF in patients with CRAO or CRVO. Data from each study were combined using the random-effects model. Results: Eleven studies were included in our meta-analysis, involving a total population of 12,305 subjects with retinal vessel occlusion. The prevalence of AF ranged from 4.1% to 21.4% (pooled prevalence = 11.5%, 95% CI: 7.0-16.1, I2 = 96.3%). Five studies reported a control group of patients without retinal vessel occlusion. We found that AF is significantly associated with retinal vessel occlusion (pooled OR = 2.24, 95% CI:2.07-2.43, I2 = 0.0%). Conclusion: Our study showed that AF is significantly associated with retinal vessel occlusion. Further studies are needed to fully elucidate the exact mechanism linking AF with CRAO and CRVO.
Objective: Recent studies have shown that atrial fibrillation (AF) is more prevalent in patients with retinal vessel occlusion and may be associated with both central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO). However, there is no systematic review and meta-analysis to confirm this finding. Methods: We searched the databases of MEDLINE and EMBASE from inception to January 2019. Included studies were published cohort, case-control or cross-sectional studies, and randomized control trials reporting the prevalence of AF in patients with CRAO or CRVO. Data from each study were combined using the random-effects model. Results: Eleven studies were included in our meta-analysis, involving a total population of 12,305 subjects with retinal vessel occlusion. The prevalence of AF ranged from 4.1% to 21.4% (pooled prevalence = 11.5%, 95% CI: 7.0-16.1, I2 = 96.3%). Five studies reported a control group of patients without retinal vessel occlusion. We found that AF is significantly associated with retinal vessel occlusion (pooled OR = 2.24, 95% CI:2.07-2.43, I2 = 0.0%). Conclusion: Our study showed that AF is significantly associated with retinal vessel occlusion. Further studies are needed to fully elucidate the exact mechanism linking AF with CRAO and CRVO.
Authors: Sonja Schönecker; Johannes Wischmann; Dennis C Thunstedt; Katharina Feil; Marc J Mackert; Siegfried Priglinger; Lars Kellert Journal: Life (Basel) Date: 2022-08-22