T L Moore1, B G E Bowley1, M A Pessina1, S M Calderazzo1, M Medalla1, V Go2, Z G Zhang3, M Chopp3, S Finklestein4,5, A G Harbaugh6, D L Rosene1, B Buller3. 1. Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA. 2. Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA. 3. Department of Neurology, Henry Ford Health Systems, Detroit, MI, USA. 4. Stemetix, Inc. Needham, MA, USA. 5. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 6. Department Mathematics & Statistics, Boston University, Boston, MA, USA.
Abstract
BACKGROUND: Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke. OBJECTIVE: Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury. METHODS: After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks. RESULTS: Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery. CONCLUSIONS: These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of motor function.
BACKGROUND: Exosomes from mesenchymal stromal cells (MSCs) are endosome-derived vesicles that have been shown to enhance functional recovery in rodent models of stroke. OBJECTIVE: Building on these findings, we tested exosomes as a treatment in monkeys with cortical injury. METHODS: After being trained on a task of fine motor function of the hand, monkeys received a cortical injury to the hand representation in primary motor cortex. Twenty-four hours later and again 14 days after injury, monkeys received exosomes or vehicle control. Recovery of motor function was followed for 12 weeks. RESULTS: Compared to monkeys that received vehicle, exosome treated monkeys returned to pre-operative grasp patterns and latency to retrieve a food reward in the first three-five weeks of recovery. CONCLUSIONS: These results provide evidence that in monkeys exosomes delivered after cortical injury enhance recovery of motor function.
Authors: Tara L Moore; Monica A Pessina; Seth P Finklestein; Brian C Kramer; Ronald J Killiany; Douglas L Rosene Journal: Somatosens Mot Res Date: 2013-06-12 Impact factor: 1.111
Authors: Donald G Phinney; Michelangelo Di Giuseppe; Joel Njah; Ernest Sala; Sruti Shiva; Claudette M St Croix; Donna B Stolz; Simon C Watkins; Y Peter Di; George D Leikauf; Jay Kolls; David W H Riches; Giuseppe Deiuliis; Naftali Kaminski; Siddaraju V Boregowda; David H McKenna; Luis A Ortiz Journal: Nat Commun Date: 2015-10-07 Impact factor: 14.919
Authors: Veronica Go; Bethany G E Bowley; Monica A Pessina; Zheng Gang Zhang; Michael Chopp; Seth P Finklestein; Douglas L Rosene; Maria Medalla; Benjamin Buller; Tara L Moore Journal: Geroscience Date: 2019-11-06 Impact factor: 7.713
Authors: Maria Medalla; Wayne Chang; Samantha M Calderazzo; Veronica Go; Alexandra Tsolias; Joseph W Goodliffe; Dhruba Pathak; Diego De Alba; Monica Pessina; Douglas L Rosene; Benjamin Buller; Tara L Moore Journal: J Neurosci Date: 2020-04-02 Impact factor: 6.167
Authors: Veronica Go; Deniz Sarikaya; Yuxin Zhou; Bethany G E Bowley; Monica A Pessina; Douglas L Rosene; Zheng Gang Zhang; Michael Chopp; Seth P Finklestein; Maria Medalla; Benjamin Buller; Tara L Moore Journal: Exp Neurol Date: 2020-11-29 Impact factor: 5.330