Literature DB >> 23758412

Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey.

Tara L Moore1, Monica A Pessina, Seth P Finklestein, Brian C Kramer, Ronald J Killiany, Douglas L Rosene.   

Abstract

We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity.

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Year:  2013        PMID： 23758412      PMCID： PMC6503838          DOI： 10.3109/08990220.2013.790806

Source DB:  PubMed          Journal:  Somatosens Mot Res        ISSN： 0899-0220            Impact factor:   1.111


  12 in total

1.  Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey.

Authors:  Tara L Moore; Monica A Pessina; Seth P Finklestein; Ronald J Killiany; Bethany Bowley; Larry Benowitz; Douglas L Rosene
Journal:  Restor Neurol Neurosci       Date:  2016-09-21       Impact factor: 2.406

2.  Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity.

Authors:  Sehwon Koh; William J Chen; Nadine S Dejneka; Ian R Harris; Bin Lu; Sergey Girman; Joshua Saylor; Shaomei Wang; Cagla Eroglu
Journal:  J Neurosci       Date:  2018-02-05       Impact factor: 6.167

3.  Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey.

Authors:  Tara L Moore; Bethany G E Bowley; Penny L Shultz; Samantha M Calderazzo; Eli J Shobin; Ajay R Uprety; Douglas L Rosene; Mark B Moss
Journal:  Somatosens Mot Res       Date:  2018-02-15       Impact factor: 1.111

4.  Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury.

Authors:  Mary E Orczykowski; Samantha M Calderazzo; Eli Shobin; Monica A Pessina; Adrian L Oblak; Seth P Finklestein; Brian C Kramer; Farzad Mortazavi; Douglas L Rosene; Tara L Moore
Journal:  Brain Res       Date:  2019-04-15       Impact factor: 3.252

5.  Advancing research in regeneration and repair of the motor circuitry: non-human primate models and imaging scales as the missing links for successfully translating injectable therapeutics to the clinic.

Authors:  Magdalini Tsintou; Kyriakos Dalamagkas; Nikos Makris
Journal:  Int J Stem Cell Res Ther       Date:  2016-10-28

6.  Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury.

Authors:  T L Moore; B G E Bowley; M A Pessina; S M Calderazzo; M Medalla; V Go; Z G Zhang; M Chopp; S Finklestein; A G Harbaugh; D L Rosene; B Buller
Journal:  Restor Neurol Neurosci       Date:  2019       Impact factor: 2.406

7.  Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.

Authors:  Veronica Go; Deniz Sarikaya; Yuxin Zhou; Bethany G E Bowley; Monica A Pessina; Douglas L Rosene; Zheng Gang Zhang; Michael Chopp; Seth P Finklestein; Maria Medalla; Benjamin Buller; Tara L Moore
Journal:  Exp Neurol       Date:  2020-11-29       Impact factor: 5.330

8.  A method for assessing recovery of fine motor function of the hand in a rhesus monkey model of cortical injury: an adaptation of the Fugl-Meyer Scale and Eshkol-Wachman Movement Notation.

Authors:  Monica A Pessina; Bethany G E Bowley; Douglas L Rosene; Tara L Moore
Journal:  Somatosens Mot Res       Date:  2019-03       Impact factor: 1.126

9.  Cell based therapy enhances activation of ventral premotor cortex to improve recovery following primary motor cortex injury.

Authors:  Mary E Orczykowski; Kevin R Arndt; Lauren E Palitz; Brian C Kramer; Monica A Pessina; Adrian L Oblak; Seth P Finklestein; Farzad Mortazavi; Douglas L Rosene; Tara L Moore
Journal:  Exp Neurol       Date:  2018-03-11       Impact factor: 5.620

10.  Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins.

Authors:  Sehwon Koh; Namsoo Kim; Henry H Yin; Ian R Harris; Nadine S Dejneka; Cagla Eroglu
Journal:  J Neurosci       Date:  2015-11-25       Impact factor: 6.167
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