Literature DB >> 31279569

Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity.

Alex Zhavoronkov1, Polina Mamoshina2.   

Abstract

First published in 2016, predictors of chronological and biological age developed using deep learning (DL) are rapidly gaining popularity in the aging research community. These deep aging clocks can be used in a broad range of applications in the pharmaceutical industry, spanning target identification, drug discovery, data economics, and synthetic patient data generation. We provide here a brief overview of recent advances in this important subset, or perhaps superset, of aging clocks that have been developed using artificial intelligence (AI).
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  aging research; artificial intelligence; biomarker development; drug discovery

Mesh:

Substances:

Year:  2019        PMID: 31279569     DOI: 10.1016/j.tips.2019.05.004

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN: 0165-6147            Impact factor:   14.819


  14 in total

1.  Considerations Regarding Public Use of Longevity Interventions.

Authors:  Yasmine J Liu; Rebecca L McIntyre; Georges E Janssens
Journal:  Front Aging       Date:  2022-04-25

Review 2.  Antiaging diets: Separating fact from fiction.

Authors:  Mitchell B Lee; Cristal M Hill; Alessandro Bitto; Matt Kaeberlein
Journal:  Science       Date:  2021-11-19       Impact factor: 63.714

3.  Does Modulation of an Epigenetic Clock Define a Geroprotector?

Authors:  Nicholas J Schork; Brett Beaulieu-Jones; Winnie Liang; Susan Smalley; Laura H Goetz
Journal:  Adv Geriatr Med Res       Date:  2022-03-29

Review 4.  Deep biomarkers of aging and longevity: from research to applications.

Authors:  Alex Zhavoronkov; Ricky Li; Candice Ma; Polina Mamoshina
Journal:  Aging (Albany NY)       Date:  2019-11-25       Impact factor: 5.682

5.  Unite to predict.

Authors:  Meeraj Kothari; Daniel W Belsky
Journal:  Elife       Date:  2021-02-12       Impact factor: 8.140

Review 6.  ARDD 2020: from aging mechanisms to interventions.

Authors:  Garik V Mkrtchyan; Kotb Abdelmohsen; Pénélope Andreux; Ieva Bagdonaite; Nir Barzilai; Søren Brunak; Filipe Cabreiro; Rafael de Cabo; Judith Campisi; Ana Maria Cuervo; Marco Demaria; Collin Y Ewald; Evandro Fei Fang; Richard Faragher; Luigi Ferrucci; Adam Freund; Carlos G Silva-García; Anastasia Georgievskaya; Vadim N Gladyshev; David J Glass; Vera Gorbunova; Aubrey de Grey; Wei-Wu He; Jan Hoeijmakers; Eva Hoffmann; Steve Horvath; Riekelt H Houtkooper; Majken K Jensen; Martin Borch Jensen; Alice Kane; Moustapha Kassem; Peter de Keizer; Brian Kennedy; Gerard Karsenty; Dudley W Lamming; Kai-Fu Lee; Nanna MacAulay; Polina Mamoshina; Jim Mellon; Marte Molenaars; Alexey Moskalev; Andreas Mund; Laura Niedernhofer; Brenna Osborne; Heidi H Pak; Andrey Parkhitko; Nuno Raimundo; Thomas A Rando; Lene Juel Rasmussen; Carolina Reis; Christian G Riedel; Anais Franco-Romero; Björn Schumacher; David A Sinclair; Yousin Suh; Pam R Taub; Debra Toiber; Jonas T Treebak; Dario Riccardo Valenzano; Eric Verdin; Jan Vijg; Sergey Young; Lei Zhang; Daniela Bakula; Alex Zhavoronkov; Morten Scheibye-Knudsen
Journal:  Aging (Albany NY)       Date:  2020-12-30       Impact factor: 5.682

Review 7.  The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19.

Authors:  Evelyne Bischof; Richard C Siow; Alex Zhavoronkov; Matt Kaeberlein
Journal:  Lancet Healthy Longev       Date:  2021-02-03

8.  DeepMAge: A Methylation Aging Clock Developed with Deep Learning.

Authors:  Fedor Galkin; Polina Mamoshina; Kirill Kochetov; Denis Sidorenko; Alex Zhavoronkov
Journal:  Aging Dis       Date:  2021-08-01       Impact factor: 6.745

9.  Radioprotectors.org: an open database of known and predicted radioprotectors.

Authors:  Alexander M Aliper; Marine E Bozdaganyan; Viktoria A Sarkisova; Alexander P Veviorsky; Ivan V Ozerov; Philipp S Orekhov; Mikhail B Korzinkin; Alexey Moskalev; Alex Zhavoronkov; Andreyan N Osipov
Journal:  Aging (Albany NY)       Date:  2020-08-15       Impact factor: 5.682

Review 10.  Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention.

Authors:  Xudong Zhu; Zhiyang Chen; Weiyan Shen; Gang Huang; John M Sedivy; Hu Wang; Zhenyu Ju
Journal:  Signal Transduct Target Ther       Date:  2021-06-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.